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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Differential regulation of brown adipose and splanchnic sympathetic outflows in rat: roles of raphe and rostral ventrolateral medulla neurons.
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Differential regulation of brown adipose and splanchnic sympathetic outflows in rat: roles of raphe and rostral ventrolateral medulla neurons.

机译：大鼠棕色脂肪和内脏交感性流出的差异调节：缝线和延髓腹侧延髓神经元的作用。

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摘要

1. The medullary premotor neurons determining the sympathetic outflow regulating cardiac function and vasoconstriction are located in the rostral ventrolateral medulla (RVLM). The present study sought evidence for an alternative location for the sympathetic premotor neurons determining the sympathetic nerve activity (SNA) controlling brown adipose tissue (BAT) metabolism and thermogenesis. 2. The tonic discharge on sympathetic nerves is determined by the inputs to functionally specific sympathetic preganglionic neurons from supraspinal populations of premotor neurons. Under normothermic conditions, BAT SNA was nearly silent, while splanchnic (SPL) SNA, controlling mesenteric vasoconstriction, exhibited sustained large-amplitude bursts. 3. The rostral raphe pallidus (RPa) contains potential sympathetic premotor neurons that project to the region of sympathetic preganglionic neurons in the thoracic spinal cord. Disinhibition of neurons in RPa elicited a dramatic increase in BAT SNA, with only a small rise in SPL SNA. 4. Splanchnic SNA was strongly influenced by the baroreceptor reflex, as indicated by a high coherence with the arterial pressure wave, a significant amplitude modulation over the time-course of the cardiac cycle and a marked inhibition of SPL SNA during a sustained increase in arterial pressure. When activated, the bursts in BAT SNA exhibited no correlation with arterial pressure and were not affected by increases in arterial pressure. 5. Because these characteristics and reflex responses in sympathetic outflow have been shown to arise from the on-going or altered discharge of sympathetic premotor neurons, the marked differences between SPL and BAT SNA provide strong evidence supporting the hypothesis that vasoconstriction and thermogenesis (metabolism) are controlled by distinct populations of sympathetic premotor neurons, the former in the RVLM and the latter, potentially, in the RPa.
机译：1.决定交感神经流出调节心脏功能和血管收缩的延髓运动前神经元位于延髓腹侧延髓（RVLM）中。本研究寻求交感神经运动前神经元的另一位置的证据，该交感神经运动前神经元确定控制棕色脂肪组织（BAT）代谢和生热的交感神经活动（SNA）。 2.交感神经上的强直性放电是由运动前神经元的脊柱上神经群功能特定的交感神经节前神经元的输入决定的。在常温条件下，BAT SNA几乎保持沉默，而控制肠系膜血管收缩的内脏（SPL）SNA表现出持续的大振幅爆发。 3.眼睑睑裂（RPa）包含潜在的交感神经运动前神经元，这些神经元投射到胸脊髓的交感神经节前神经元区域。 RPa中神经元的抑制引起BAT SNA的急剧增加，而SPL SNA的增加很小。 4.内脏SNA受压力感受器反射的强烈影响，表现为与动脉压波的高度连贯性，在心动周期的整个时间过程中明显的幅度调制以及在动脉持续增加期间对SPL SNA的显着抑制压力。激活后，BAT SNA中的爆发与动脉压无关，也不受动脉压升高的影响。 5.由于交感神经外流的这些特征和反射反应已经显示出是由交感神经前运动神经元的持续或改变放电引起的，因此SPL和BAT SNA之间的明显差异提供了有力的证据，支持了血管收缩和生热（代谢）的假说它们受交感神经运动前神经元的不同群体控制，前者在RVLM中，后者可能在RPa中。

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