...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental pharmacology & physiology >Differential patterns of regional neuroadrenergic cardiovascular drive in acromegalic disease
【24h】

Differential patterns of regional neuroadrenergic cardiovascular drive in acromegalic disease

机译：肢端肥大症疾病中区域性神经肾上腺素能心血管驱动的差异模式

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It has been shown that acromegaly is characterized by an autonomic imbalance and by marked sympathoinhibition. However, there is no information available as to whether adrenergic inhibition is confined to selected vascular districts or, rather, is generalized. We examined 17 newly diagnosed active acromegalic patients without hyperprolactinaemia, pituitary hormone deficiencies, obstructive sleep apnoea and cardiac hypertrophy and 14 healthy subjects matched for age, sex and body mass index. For each subject, we collected information regarding anthropometric parameters and echocardiography, and collected plasma samples to investigate anterior pituitary function, glucose and lipid metabolism and plasma leptin levels. Beat-to-beat mean arterial pressure, heart rate and efferent post-ganglionic muscle and skin sympathetic nerve traffic (MSNA and SSNA, respectively; determined by microneurography) were measured. Both MSNA and SSNA were recorded in a randomized sequence over two 30 min periods. Measurements also included evaluation of SSNA responses to emotional stimulus. In addition to significant reductions in plasma leptin levels, acromegalic patients had markedly decreased MSNA compared with the healthy controls. There were no significant differences in SSNA between the two groups, either under basal conditions or in responses to arousal stimuli. There was a significant and direct correlation between MSNA and plasma leptin levels, but not between plasma leptin and SSNA. These data provide the first evidence that the sympathetic inhibition characterizing the early phase of acromegaly is not generalized to the entire cardiovascular system.
机译：已经显示肢端肥大症的特征是自主神经失调和明显的交感神经抑制。但是，没有关于肾上腺素能抑制作用仅限于特定血管区域还是被普遍推广的信息。我们检查了17名新诊断的活动性肢端肥大症患者，无高泌乳​​素血症，垂体激素缺乏症，阻塞性睡眠呼吸暂停和心脏肥大，以及14例年龄，性别和体重指数匹配的健康受试者。对于每个受试者，我们收集了有关人体测量学参数和超声心动图的信息，并收集了血浆样本以研究垂体前叶功能，葡萄糖和脂质代谢以及血浆瘦素水平。测量搏动的平均动脉压，心率以及神经节后肌肉和皮肤的交感神经传出流量（分别为MSNA和SSNA;通过微神经图测定）。 MSNA和SSNA均在两个30分钟的时间内以随机顺序记录。测量还包括评估SSNA对情绪刺激的反应。除血浆瘦素水平显着降低外，与健康对照组相比，肢端肥大症患者的MSNA明显降低。两组在基础条件下或对刺激刺激的反应中，SSNA均无显着差异。 MSNA与血浆瘦素水平之间存在显着且直接的相关性，但血浆瘦素与SSNA之间没有显着和直接的相关性。这些数据提供了第一个证据，即肢端肥大症早期阶段的交感神经抑制作用并未推广到整个心血管系统。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号