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首页> 外文期刊>Clinical and experimental pharmacology & physiology >Differential patterns of sympathetic responses to selective stimulation of nucleus tractus solitarius purinergic receptor subtypes.
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Differential patterns of sympathetic responses to selective stimulation of nucleus tractus solitarius purinergic receptor subtypes.

机译：选择性刺激孤索核嘌呤嘌呤能受体亚型的交感反应的差异模式。

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摘要

1. Studies are described that indicate that stimulation of different purinergic receptor subtypes (A1, A2A and P2X) located in the sub-postremal nucleus tractus solitarius (NTS) evokes qualitatively and quantitatively different regional haemodynamic and efferent sympathetic responses. 2. Stimulation of A2A receptors evoked the most diverse pattern of regional sympathetic responses: preganglionic adrenal nerve activity (pre-ASNA) was increased, lumbar sympathetic nerve activity (LSNA) did not change, while renal (RSNA) and post-ganglionic adrenal (post-ASNA) sympathetic nerve activity was decreased. Stimulation of A1 receptors evoked qualitatively uniform, although quantitatively different, sympathoactivation: pre-ASNA > RSNA > LSNA. Stimulation of P2X receptors evoked qualitatively uniform, although quantitatively different, sympathoinhibition: RSNA=post-ASNA > LSNA = pre-ASNA. 3. These qualitatively and quantitatively different patterns of regional sympathetic responses strongly suggest that purinergic receptor subtypes may be specifically located and differentially expressed on NTS neuronseural terminals that control different sympathetic outputs. Different NTS purinoceptors may contribute to patterned autonomic responses observed in specific physiological or pathological situations.
机译：1.研究表明，刺激对孤雌性核束旁核（NTS）的不同嘌呤能受体亚型（A1，A2A和P2X）的刺激会在质量和数量上引起不同的区域血流动力学和传出的交感神经反应。 2.刺激A2A受体引起了最广泛的区域性交感神经反应：神经节前肾上腺神经活动（ASNA）增加，腰交感神经活动（LSNA）没有改变，而肾（RSNA）和神经节后肾上腺（ ASNA后）交感神经活动减少。尽管数量上不同，但对A1受体的刺激在质量上是一致的，即交感神经激活：ASNA前> RSNA> LSNA。尽管数量上不同，但对P2X受体的刺激在质量上是一致的，即交感神经抑制：RSNA = ASNA后> LSNA = ASNA前。 3.这些定性和定量上不同的区域交感神经反应模式强烈表明，嘌呤能受体亚型可能在控制不同交感神经输出的NTS神经元/神经末梢上特异性定位并差异表达。不同的NTS嘌呤受体可能有助于在特定生理或病理情况下观察到的模式自主神经反应。

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