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首页> 外文期刊>Biomacromolecules >Biocompatible Glycopolymer Nanocapsules via Inverse Miniemulsion Periphery RAFT Polymerization for the Delivery of Gemcitabine
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Biocompatible Glycopolymer Nanocapsules via Inverse Miniemulsion Periphery RAFT Polymerization for the Delivery of Gemcitabine

机译：生物相容性糖聚合物纳米胶囊通过逆向微乳液外围RAFT聚合来传递吉西他滨

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摘要

Encapsulation of hydrophilic cancer drugs in polymeric nanocapsules was achieved in a one-pot process via the inverse miniemulsion periphery RAFT polymerization (IMEPP) approach. The chosen guest molecule was gemcitabine hydrochloride, which is used as the first-line treatment of pancreatic cancer. The resulting nanocapsules were confirmed to be similar to 200 nm, with excellent encapsulation (similar to 96%) and loading (similar to 12%) efficiency. Postpolymerization reaction was successfully conducted to create glyocopolymer nanocapsules without any impact on the loads as well as the nanocapsules size or morphology. The loaded nanocapsules were specifically designed to be responsive in a reductive environment. This was confirmed by the successful disintegration of the nanocapsules in the presence of glutathione. The gemcitabine-loaded nanocapsules were tested in vitro against pancreatic cancer cells (AsPC-1), with the results showing an enhancement in the cytotoxicity by two fold due to selective accumulation and release of the nanocapsules within the cells. The results demonstrated the versatility of IMEPP as a tool to synthesize functionalized, loaded-polymeric nanocapsules suitable for drug-delivery application.
机译：通过逆向细乳液外围RAFT聚合（IMEPP）方法，通过一锅法将亲水性癌症药物包封在聚合物纳米胶囊中。选择的客体分子是盐酸吉西他滨，它被用作胰腺癌的一线治疗。确认所得的纳米胶囊与200 nm相似，具有出色的封装（接近96％）和负载（接近12％）效率。成功地进行了后聚合反应，以生成含羟基共聚物的纳米胶囊，而对负载以及纳米胶囊的大小或形态没有任何影响。负载的纳米胶囊经过专门设计，可在还原性环境中起反应。在存在谷胱甘肽的情况下纳米胶囊的成功崩解证实了这一点。载有吉西他滨的纳米胶囊在体外针对胰腺癌细胞（AsPC-1）进行了测试，结果显示由于细胞内纳米胶囊的选择性积累和释放，细胞毒性提高了两倍。结果表明，IMEPP作为合成适合药物递送应用的功能化，负载型聚合物纳米胶囊的工具具有多功能性。

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