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首页> 外文期刊>Biomacromolecules >Carboxylated Agarose (CA)-Silk Fibroin (SF) Dual Confluent Matrices Containing Oriented Hydroxyapatite (HA) Crystals: Biomimetic Organic/Inorganic Composites for Tibia Repair
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Carboxylated Agarose (CA)-Silk Fibroin (SF) Dual Confluent Matrices Containing Oriented Hydroxyapatite (HA) Crystals: Biomimetic Organic/Inorganic Composites for Tibia Repair

机译：含定向羟基磷灰石（HA）晶体的羧化琼脂糖（CA）-丝素蛋白（SF）双汇合基质：用于胫骨修复的仿生有机/无机复合材料

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摘要

By in situ combining the dual cross-linking matrices of the carboxylated agarose (CA) and the silk fibroin (SF) with the hydroxyapatite (HA) crystals, the CA-SF/HA composites with optimal physicochemical and biological properties were obtained, which were designed to meet the clinical needs of load-bearing bone repair. With the synergistic modulation of the dual organic matrices, the HA nanoparticles presented sheet and rod morphologies due to the preferred orientation, which successfully simulated the biomineralization in nature. The chemical reactivity of the native agarose (NA) was significantly enhanced via carboxylation, and the CA exhibited higher thermal stability than the NA. In the presence of SF, the composites showed optimal mechanical properties that could meet the standard of bone repair. The degradation of the composites in the presence of CA and SF was significantly delayed such that the degradation rate of the implant could satisfy the growth rate of the newly formed bone tissue. The in vitro tests confirmed that the CA-SF/HA composite scaffolds enabled the MG63 cells to proliferate and differentiate well, and the CA/HA composite presented greater capability of promoting the cell behaviors than the NA/HA composite. After 24 days of implantation, newly formed bone was observed at the tibia defect site and around the implant. Extensive osteogenesis was presented in the rats treated with the CA-SF/HA composites. In general, the CA-SF/HA composites prepared in this work had the great potential to be applied for repairing large bone defects.
机译：通过将羧化琼脂糖（CA）和丝素蛋白（SF）的双重交联基质与羟基磷灰石（HA）晶体原位结合，获得具有最佳理化和生物学特性的CA-SF / HA复合材料，旨在满足承重骨修复的临床需求。通过双重有机基质的协同调节，HA纳米颗粒由于具有较好的取向性而呈现出片状和棒状形态，从而成功地模拟了自然的生物矿化作用。天然琼脂糖（NA）的化学反应性通过羧化显着增强，并且CA显示出比NA高的热稳定性。在SF存在下，复合材料显示出可以满足骨修复标准的最佳机械性能。在CA和SF的存在下复合材料的降解被显着延迟，使得植入物的降解速率可以满足新形成的骨组织的生长速率。体外测试证实，CA-SF / HA复合材料支架能够使MG63细胞良好增殖和分化，并且CA / HA复合材料比NA / HA复合材料具有更大的促进细胞行为的能力。植入24天后，在胫骨缺损部位和植入物周围观察到新形成的骨头。在用CA-SF / HA复合材料治疗的大鼠中表现出广泛的成骨作用。通常，在这项工作中制备的CA-SF / HA复合材料具有巨大的潜力可用于修复大的骨缺损。

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