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首页> 外文期刊>Clinical and investigative medicine: Medecine clinique et experimentale >A comparative study of insulin lispro and human regular insulin in patients with type 2 diabetes mellitus and secondary failure of oral hypoglycemic agents.
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A comparative study of insulin lispro and human regular insulin in patients with type 2 diabetes mellitus and secondary failure of oral hypoglycemic agents.

机译：赖脯胰岛素和人常规胰岛素在2型糖尿病和继发性口服降糖药继发性衰竭患者中的​​比较研究。

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OBJECTIVE: To compare the effects of insulin lispro (LP) and human regular insulin (HR) when given twice daily with NPH insulin on glycemic control (HbA1c), daily blood glucose profiles and rates of hypoglycemia in patients with type 2 diabetes mellitus after failure to respond to sulfonylurea drugs. RESEARCH DESIGN AND METHODS: A 5.5-month randomized, open-label, parallel study of 148 patients receiving either LP (n = 70) or HR (n = 78). Eight-point blood glucose profiles and HbA1c measurements were collected at baseline, 1.5, 3.5 and 5.5 months. RESULTS: Two-hour post-breakfast and 2-hour post-supper blood glucose levels (means [and standard errors]) were significantly lower for LP than for HR at the end point (9.5 [0.4] mmol/L v. 10.9 [0.4] mmol/L and 8.4 [0.4] mmol/L v. 9.7 [0.4] mmol/L, respectively, p = 0.02 in both cases). HbA1c improved from 10.5% (0.2%) (LP) and 10.3% (0.2%) (HR) to 8.0% (0.1%). Hypoglycemia rates were similar during the day; however, there was an overnight trend to reduced rates with LP (0.08 [0.03] episodes/30 d v. 0.16 [0.04] episodes/30 d, p = 0.057). Quality-of life assessment showed significant improvement (p < 0.05) in the diabetes-related worry scale for LP subjects whereas HR subjects slightly worsened. CONCLUSIONS: With traditional twice-daily insulin administration algorithms, LP improves 2-hour postprandial glucose levels, quality of life and overnight hypoglycemia rates while delivering an equivalent level of glycemic control (HbA1c) compared with HR to insulin-naive patients with type 2 diabetes who require insulin.
机译：目的：比较每日两次与NPH胰岛素一起给予赖脯胰岛素（LP）和人常规胰岛素（HR）对2型糖尿病患者衰竭后血糖控制（HbA1c），每日血糖谱和低血糖发生率的影响对磺酰脲类药物有反应。研究设计与方法：一项为期5.5个月的随机，开放标签，平行研究，对148名接受LP（n = 70）或HR（n = 78）的患者进行了研究。在基线，1.5、3.5和5.5个月时收集八点血糖曲线和HbA1c测量值。结果：早餐后2小时和术后2小时的血糖水平（平均值[和标准误差]）显着低于终点的HR（9.5 [0.4] mmol / L v。10.9 [ 0.4] mmol / L和8.4 [0.4] mmol / L v。9.7 [0.4] mmol / L，在两种情况下p = 0.02）。 HbA1c从10.5％（0.2％）（LP）和10.3％（0.2％）（HR）提高到8.0％（0.1％）。白天的低血糖发生率相似;然而，LP的发生率呈下降趋势的一夜趋势（0.08 [0.03]集/ 30 d对0.16 [0.04]集/ 30 d，p = 0.057）。生活质量评估显示，与LP相关的糖尿病相关的忧虑量表显着改善（p <0.05），而HR相关的受试者则稍有恶化。结论：通过传统的每日两次胰岛素给药算法，LP可以为未使用胰岛素的2型糖尿病患者提供2小时的餐后血糖水平，生活质量和夜间低血糖率，同时提供与HR相当的血糖控制（HbA1c）水平。需要胰岛素的人

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