...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and investigative medicine: Medecine clinique et experimentale >Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification.
【24h】

Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification.

机译：根据Framingham风险分层评估低心血管事件风险患者中的新危险因素。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Coronary heart disease (CHD) risk assessed by the Framingham risk score does not take into account the various "novel" markers that are of increasing interest. In this paper we examine a low-risk population to determine which novel markers may be of additive value to the Framingham assessment of CHD risk. METHODS: Levels of high-sensitivity C-reactive protein (hs-CRP), soluble vascular cell adhesion molecule (s-VCAM), soluble intercellular adhesion molecule (s-ICAM-1), endothelial selectin (e-selectin), homocysteine and von Willebrand factor (vWF) were measured in 53 apparently healthy subjects recruited from a risk-reduction referral clinic. Carotid intima medial thickness (IMT) and number of plaques were determined by ultrasonography. Brachial ultrasound flow-mediated dilation (FMD) was also measured. Framingham risk scores were calculated and univariate and multivariate analyses of the resulting percent CHD risk over 10 years and novel markers were undertaken. RESULTS: Abnormal carotid IMT and presence of plaques, hs-CRP, homocysteine, FMD and s-ICAM-1 were detected with a high frequency in this low-risk cohort. Average IMT, number of plaques and homocysteine were highly correlated with the calculated percent CHD whereas measures of hs-CRP, s-ICAM-1 and FMD were independent of the percent CHD calculation. CONCLUSIONS: FMD, as a reflection of the functional status of the vasculature, and hs-CRP and s-ICAM-1, as indicators of inflammatory processes, were independent of Framingham risk assessment in patients at low risk for cardiovascular disease.
机译：背景：通过弗雷明汉（Framingham）风险评分评估的冠心病（CHD）风险未考虑人们越来越感兴趣的各种“新颖”标记。在本文中，我们研究了低风险人群，以确定哪些新标记物可能对Framingham评估CHD风险具有附加价值。方法：高敏C反应蛋白（hs-CRP），可溶性血管细胞粘附分子（s-VCAM），可溶性细胞间粘附分子（s-ICAM-1），内皮选择素（e-selectin），同型半胱氨酸和von Willebrand因子（vWF）在从降低风险的转诊诊所招募的53名明显健康的受试者中进行了测量。通过超声检查确定颈动脉内膜中层厚度（IMT）和斑块数量。还测量了肱超声流介导的扩张（FMD）。计算弗雷明汉（Framingham）风险评分，并对10年内产生的冠心病风险百分比进行单变量和多变量分析，并进行新的标记。结果：在该低危人群中，高频率检测到颈动脉IMT异常和斑块，hs-CRP，高半胱氨酸，FMD和s-ICAM-1的存在。平均IMT，斑块和高半胱氨酸数量与计算的CHD百分比高度相关，而hs-CRP，s-ICAM-1和FMD的测量值与CHD百分比计算无关。结论：FMD（反映血管系统的功能状态）和hs-CRP和s-ICAM-1（作为炎症过程的指标）独立于低心血管疾病患者的Framingham风险评估。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号