Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.

Newman B; Siminovitch K

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Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.

机译：炎症性肠病：克罗恩病和现代遗传学的成功。

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The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are multifactorial in etiology, but a major causative role for genetic factors has long been recognized. Recent advances in genetic technologies have made dissection of the genes underlying common diseases possible; consequently, there is an emerging understanding of the inherited factors that predispose to IBD. In this review, we summarize current information on the genetics of IBD, emphasizing the discovery of CARD15 variants as susceptibility alleles for Crohn's disease and the impact of this discovery on patient care and in delineating pathogenesis of this complex disease.

机译：炎症性肠病（IBDs），克罗恩氏病和溃疡性结肠炎在病因上是多因素的，但是人们早已认识到遗传因素的主要诱因。基因技术的最新进展使得解剖常见疾病的基因成为可能。因此，人们对IBD的遗传因素有了新的认识。在这篇综述中，我们总结了有关IBD遗传学的最新信息，强调了发现CARD15变异体作为克罗恩病的易感性等位基因，以及该发现对患者护理的影响以及对这种复杂疾病的发病机理的描述。

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《Clinical and investigative medicine: Medecine clinique et experimentale》 |2003年第6期|共12页
作者
Newman B; Siminovitch K;
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正文语种 eng
中图分类基础医学;
关键词
Crohn's disease; Inflammatory Bowel Diseases; genetic aspects; success; Genetic; 炎性肠疾病;

机译：Crohn's disease;Inflammatory Bowel Diseases;genetic aspects;success;Genetic;炎性肠疾病;

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1. Inflammatory bowel disease: Crohn's disease and the success of NODern genetics. [J] . Newman B, Siminovitch K Clinical and investigative medicine: Medecine clinique et experimentale . 2003,第6期

机译：炎症性肠病：克罗恩病和现代遗传学的成功。
2. Chronic inflammatory bowel diseases: Mucosal healing as a new goal in Crohn's disease [Chronisch entzündliche darmkrankheiten: Mukosaheilung als neues ziel bei Morbus Crohn] [J] . BischoffA. Der Klinikarzt . 2009,第5期

机译：慢性炎症性肠病：克罗恩病的新目标是粘膜愈合[慢性炎症性肠病：克罗恩病的新目标是粘膜愈合
3. Chronic inflammatory bowel diseases: Mucosal healing as a new goal in Crohn's disease [Chronisch entzündliche darmkrankheiten: Mukosaheilung als neues ziel bei Morbus Crohn] [J] . BischoffA. Der Klinikarzt . 2009,第5期

机译：慢性炎症性肠病：克罗恩病的新目标是粘膜愈合[慢性炎症性肠病：克罗恩病的新目标是粘膜愈合
4. Analysis of integrated inflammatory bowel disease mouse models to assess their disease driving pathways and relevance for Crohn’s disease and Ulcerative colitis [C] . Weiwei Schultz, Calixte Monast, Mathias Hesse, IEEE International Conference on Bioinformatics and Biomedicine . 2018

机译：分析综合性炎症性肠病小鼠模型以评估其疾病驱动途径以及与克罗恩病和溃疡性结肠炎的相关性
5. Diagnostic accuracy of preoperative magnetic resonance in determination of the extension and inflammatory activity of small bowel Crohn's disease. [D] . Pous Serrano, Salvador. 2014

机译：术前磁共振测定小肠克罗恩病的扩展和炎症活动的诊断准确性。
6. Protein Microarray Analysis of Disease Activity in Pediatric Inflammatory Bowel Disease Demonstrates Elevated Serum PLGF IL-7 TGF-β1 and IL-12p40 Levels in Crohn’s Disease and Ulcerative Colitis Patients in Remission versus Active Disease [O] . Howard A. Kader, Velizar T. Tchernev, Ebenezer Satyaraj, -1

机译：蛋白微阵列分析小儿炎症性肠病中疾病活动的证据表明克罗恩病和溃疡性结肠炎患者在缓解期与活动性疾病相比血清PLGFIL-7TGF-β1和IL-12p40水平升高
7. Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease [O] . Corinna Lang-Schwarz, Abbas Agaimy, Raja Atreya, 2020

机译：最大化慢性炎症性肠疾病中活组织检查的诊断信息：来自Erlangen国际共识疾病的建议和IBD-DCA展示的宣传作为溃疡性结肠炎和克罗恩病中的组织学活动评估的新指标的提案

Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.

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