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首页> 外文期刊>Clinical and investigative medicine: Medecine clinique et experimentale >Association of serum fetuin-A levels with heart valve calcication and other biomarkers of inflammation among persons with acute coronary syndrome
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Association of serum fetuin-A levels with heart valve calcication and other biomarkers of inflammation among persons with acute coronary syndrome

机译：急性冠状动脉综合征患者血清胎球蛋白A水平与心脏瓣膜钙化和其他炎症生物标志物的关系

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Purpose: Fetuin-A is a multifunctional hepatic secretory protein that inhibits dystrophic vascular and valvular calcification. Our aim was to evaluate the relationship among fetuin-A levels, heart valve calcification and other biomarkers of inflammation in patients with acute coronary syndrome (ACS). Methods: The associations among serum fetuin-A concentrations, mitral annular (MAC) and aortic valve calcification and other biomarkers of inflammation (hs-CRP, ferritin, fibrinogen, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), albumin levels) were evaluated in ACS patients and healthy controls. The study included 95 patients (mean age 61.8±12.10 years) and 81 healthy controls (mean age 48.33±9.19 years). Results: Fetuin-A levels were significantly lower in patients with ACS than in healthy controls (0.76 ± 0.23 and 1.10 ± 0.45 g/L, respectively, p<0.001). Fetuin-A was lower in patients with mitral annular calcification (p=0.007) and aortic (p=0.001) valve calcification. In patients with ACS, there was a negative correlation among serum urea (r=-0.377, p<0.001) and creatinine (r=-0.232, p=0.024) levels and fetuin-A, and a negative correlation among WBC (r=-0.156, p=0,132), ESR (r=-0.214, p=0.037), hs-CRP (r=-0.220, p=0.032) levels and fetuin-A. A positive correlation was seen between albumin and fetuin-A (r=0.362, p<0.001). Multivariate logistic regression analysis revealed that fetuin-A was the variable that had a significant effect on ACS (p = 0.020 OR = .015, (95% CI)(0.000-0.520). Conclusion, Fetuin-A levels decrease in patients with acute coronary syndromes, independent of heart valve calcification: Fetuin-A may therefore act as a negative acute phase protein after myocardial infarction.
机译：目的：Fetuin-A是一种多功能的肝分泌蛋白，可抑制营养不良的血管和瓣膜钙化。我们的目的是评估急性冠状动脉综合征（ACS）患者的胎球蛋白A水平，心脏瓣膜钙化和其他炎症生物标志物之间的关系。方法：血清胎球蛋白A浓度，二尖瓣环（MAC）和主动脉瓣钙化以及其他炎症生物标志物（hs-CRP，铁蛋白，纤维蛋白原，白细胞计数（WBC），红细胞沉降率（ESR），白蛋白之间的关系水平）在ACS患者和健康对照中进行了评估。该研究包括95位患者（平均年龄61.8±12.10岁）和81位​​健康对照（平均年龄48.33±9.19岁）。结果：ACS患者的胎球蛋白A水平显着低于健康对照组（分别为0.76±0.23和1.10±0.45 g / L，p <0.001）。二尖瓣环钙化（p = 0.007）和主动脉瓣膜钙化（p = 0.001）患者的胎球蛋白-A水平较低。在ACS患者中，血清尿素（r = -0.377，p <0.001）和肌酐（r = -0.232，p = 0.024）水平与胎球蛋白A之间呈负相关，而WBC之间呈负相关（r = -0.156，p = 0,132），ESR（r = -0.214，p = 0.037），hs-CRP（r = -0.220，p = 0.032）水平和胎球蛋白A.在白蛋白和胎球蛋白-A之间发现正相关（r = 0.362，p <0.001）。多因素logistic回归分析表明，胎球蛋白A是对ACS有显着影响的变量（p = 0.020 OR = .015，（95％CI）（0.000-0.520）。独立于心脏瓣膜钙化的冠状动脉综合征：因此，Fetuin-A可能在心肌梗塞后充当阴性急性期蛋白。

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