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Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties

机译：骨架形态参数和性质对造孔剂尺寸和含量的系统研究

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摘要

A systematic investigation of tissue engineering scaffolds prepared by salt leaching of a photopolymerized dimethacrylate was performed to determine how the scaffold structure (porosity, pore size, etc.) can be controlled and also to determine how the scaffold structure and the mechanical properties are related. Two series of scaffolds were prepared with (1) the same polymer-to-salt ratio but different salt sizes (ranging from average size of 100 to 390 mu m) and (2) the same salt size but different polymer-to-salt ratios (ranging from salt mass of 70 to 90%), These scaffolds were examined to determine how the fabrication parameters affected the scaffold morphometric parameters and corresponding mechanical properties. Combined techniques of X-ray microcomputed tomography (mu CT), mercury porosimetry, and gravimetric analysis were used to determine the scaffold parameters, such as porosity, pore size, and strut thickness and their size distributions, and pore interconnectivity. Scaffolds with porosities ranging from 57% to 92% (by volume) with interconnected structures could be fabricated using the current technique. The porosity and strut thickness were subsequently related to the mechanical response of the scaffolds, both of which contribute to the compression modulus of the scaffold. The current study shows that the structure and properties of the scaffold could be tailored by the size and the amount of porogen used in the fabrication of the scaffold.
机译：对通过光浸聚合的二甲基丙烯酸酯的盐浸制备的组织工程支架进行了系统研究，以确定如何控制支架结构（孔隙度，孔径等），并确定支架结构与机械性能之间的关系。制备了两个系列的脚手架，其中（1）相同的聚合物与盐的比率，但盐的大小不同（范围从100到390μm的平均大小），以及（2）相同的盐与大小的盐，但聚合物与盐的比率不同（盐质量范围为70％到90％），检查了这些支架以确定制造参数如何影响支架的形态参数和相应的机械性能。使用X射线计算机断层扫描（mu CT），水银孔率法和重量分析法相结合的技术来确定支架参数，例如孔隙率，孔尺寸和支杆厚度及其尺寸分布以及孔的互连性。可以使用当前技术制造具有互连结构的孔隙率为57％至92％（按体积计）的支架。孔隙率和支柱厚度随后与支架的机械响应有关，这两者都对支架的压缩模量有贡献。当前的研究表明，支架的结构和性质可以通过制造支架时使用的成孔剂的大小和量来调整。

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