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首页> 外文期刊>Clinical and investigative medicine: Medecine clinique et experimentale >Prevalence and disease associations of certain autoantibodies in elderly patients.
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Prevalence and disease associations of certain autoantibodies in elderly patients.

机译：老年患者某些自身抗体的患病率和疾病关联。

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OBJECTIVE: To determine the prevalence and association with various diseases of certain autoantibodies among elderly patients, in order to challenge the hypothesis that these autoantibodies are elevated generally in these patients as a result of immunosenescence. DESIGN: Prospective prevalence study. PATIENTS: A total of 399 elderly patients: 63 aging successfully (without chronic illness), 301 with a variety of chronic general illnesses (frail elderly) and 35 with a clinical diagnosis of rheumatoid arthritis. These were compared with 250 healthy adult blood donors. INTERVENTIONS: Measurement of autoantibodies to rheumatoid factor, antinuclear antibody, double-stranded (native) DNA (nDNA), extractable nuclear antigens and anticardiolipin antibodies. OUTCOME MEASURES: Prevalence of these autoantibodies and correlation with disease states. RESULTS: Antibodies to rheumatoid factor and antinuclear antibody were significantly more prevalent in the elderly patients with chronic illness or rheumatoid arthritis but were not disease-specific. The prevalence of nDNA and extractable nuclear antigens was not increased in either the healthy or frail elderly groups. Anticardiolipin antibodies were significantly more prevalent in the frail elderly group when compared with normal controls and the healthy elderly group. The prevalence of anticardiolipin antibodies correlated with clinical features of cerebrovascular disease, in particular multi-infarct dementia and stroke, but not with Alzheimer's disease. CONCLUSIONS: The prevalence of the autoantibodies measured was not elevated in healthy elderly subjects, and autoantibodies such as nDNA and extractable nuclear antigens are specific to disease states in all groups of elderly patients. Anticardiolipin antibodies correlate with cerebrovascular events. Therefore, the clinical significance of autoantibodies in elderly patients is related more to global health status than to the effects of aging.
机译：目的：确定老年患者中某些自身抗体的患病率及其与各种疾病的关系，以质疑免疫衰老导致这些患者体内这些自身抗体普遍升高的假说。设计：前瞻性患病率研究。患者：399名老年患者：63名成功衰老（无慢性病），301名患有各种慢性普通疾病（体弱的老人）和35名临床诊断为类风湿关节炎。将它们与250名健康的成人献血者进行了比较。干预措施：针对类风湿因子，抗核抗体，双链（天然）DNA（nDNA），可提取核抗原和抗心磷脂抗体的自身抗体的测量。观察指标：这些自身抗体的流行及其与疾病状态的相关性。结果：类风湿因子抗体和抗核抗体在患有慢性疾病或类风湿关节炎的老年患者中更为普遍，但并非具有特异性。在健康或体弱的老年人群中，nDNA和可提取核抗原的患病率均未增加。与正常对照组和健康老年人组相比，脆弱的老年人组中抗心磷脂抗体的患病率明显更高。抗心磷脂抗体的患病率与脑血管疾病，特别是多发性梗塞性痴呆和中风的临床特征有关，但与阿尔茨海默氏病无关。结论：在健康的老年受试者中，测得的自身抗体的患病率并未升高，并且诸如nDNA和可提取的核抗原之类的自身抗体对所有老年患者的疾病状态都是特定的。抗心磷脂抗体与脑血管事件相关。因此，老年患者自身抗体的临床意义更多地与整体健康状况有关，而不是与衰老的影响有关。

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