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首页> 外文期刊>Clinical and investigative medicine: Medecine clinique et experimentale >Postprandial dyspnea and malnutrition in patients with chronic obstructive pulmonary disease.
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Postprandial dyspnea and malnutrition in patients with chronic obstructive pulmonary disease.

机译：慢性阻塞性肺疾病患者的餐后呼吸困难和营养不良。

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OBJECTIVE: To compare ventilatory response, oxygen uptake and sense of dyspnea of underweight versus normal-weight patients with chronic obstructive pulmonary disease (COPD) after a standard meal, in order to investigate whether an increase in dyspnea due to diet-induced thermogenesis might lead to altered eating habits. Weight loss in patients with COPD leads to adverse health effects, but the reasons for this loss are not well understood. DESIGN: Prospective study. PARTICIPANTS: A total of 18 patients (14 men, 4 women) aged 46 to 83 with severe, stable COPD. OUTCOME MEASURES: Minute ventilation (VE), tidal volume (VT), frequency of breathing, oxygen uptake (VO2), carbon dioxide excretion (VCO2) and sense of dyspnea (using the Borg scale) were measured 15 minutes before a 2.5-MJ (600-kcal) balanced liquid meal and at four 15-minute intervals after the meal. RESULTS: Increases in VE, VT, VO2 and VCO2 were observed for all subjects. Corrected for body surface area, the maximum postprandial changes in these indicators did not differ between the underweight and the normal-weight subjects with COPD. Work of breathing (measured in 11 subjects) did not differ between the 2 groups, nor did the number of subjects reporting increased dyspnea. CONCLUSIONS: Since the increases in VE, VO2, VCO2 and perceived dyspnea did not differ between the normal-weight and underweight patients, this indicates that dyspnea at mealtimes is not likely to lead to decreased food intake.
机译：目的：比较标准餐后体重不足和正常体重的慢性阻塞性肺疾病（COPD）体重不足患者与正常体重患者的通气反应，摄氧量和呼吸困难感，以调查是否因饮食引起的热生成而导致呼吸困难增加改变饮食习惯。 COPD患者的体重减轻会导致不良的健康影响，但这种原因尚不清楚。设计：前瞻性研究。参与者：年龄在46至83岁之间的18例重度，稳定的COPD患者（14例男性，4例女性）。观察指标：在2.5 MJ前15分钟测量分钟通气量（VE），潮气量（VT），呼吸频率，摄氧量（VO2），二氧化碳排泄（VCO2）和呼吸困难感（使用Borg量表）。 （600大卡）平衡的液体餐，餐后四个15分钟间隔一次。结果：所有受试者均观察到VE，VT，VO2和VCO2升高。校正了体表面积后，这些指标的最大餐后变化在体重不足和正常体重的COPD患者之间没有差异。呼吸功（在11名受试者中进行了测量）在两组之间没有差异，报告呼吸困难增加的受试者人数也没有差异。结论：由于正常体重和体重不足患者的VE，VO2，VCO2和呼吸困难的增加没有差异，这表明就餐时的呼吸困难不太可能导致食物摄入减少。

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