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首页> 外文期刊>Clinical and laboratory haematology >Infection-associated haemophagocytosis: the tropical spectrum.
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Infection-associated haemophagocytosis: the tropical spectrum.

机译：感染相关的噬血细胞增多症：热带光谱。

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Summary Reactive proliferation and inappropriate activation of mature histiocytes with haemophagocytosis (HP) may occur in association with a wide variety of infections, neoplasms, collagen vascular diseases, and acquired and inherited immunodeficiency states. The association with infections is particularly important because overwhelming HP can obscure the typical clinical features of the primary disease and negatively affects outcome. A high index of suspicion is required for early recognition of associated HP as the cause of cytopenias. Institution of specific therapy is crucial for survival. This study highlights the wide spectrum of tropical diseases that can have associated reactive HP. Thirty cases with documented prominent HP on bone marrow aspiration smears were reviewed. Twenty-one (69%) of the marrows were from patients who had common tropical infections: malaria, typhoid and visceral leishmaniasis and 11 of 15 patients (73%) who were followed up improved on specific infection-directed and supportive measures. The presence of severe HP in bone marrow smears correlated with marked cytopenias. Recognition of HP in this geographical region should stimulate the search for one of these infections as early institution of specific therapy is crucial for patient survival.
机译：小结嗜血细胞增多症（HP）引起的成熟组织细胞的反应性增殖和不适当的激活可能与多种感染，肿瘤，胶原血管疾病以及获得性和遗传性免疫缺陷状态有关。与感染的关系尤为重要，因为压倒性的HP会掩盖原发性疾病的典型临床特征并对结果产生负面影响。为了早日识别相关的HP为血细胞减少症的原因，需要高度怀疑。特定疗法的建立对于生存至关重要。这项研究强调了与反应性HP相关的多种热带疾病。回顾了30例在骨髓抽吸涂片上有明显HP的病例。 21个骨髓（69％）来自常见热带感染患者：疟疾，伤寒和内脏利什曼病，以及15例患者中的11例（73％）接受了针对特定感染指导和支持措施的随访。骨髓涂片中严重HP的存在与明显的血细胞减少有关。在这一地理区域对HP的认识应该会刺激寻找其中一种感染，因为早期的特殊治疗对患者生存至关重要。

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