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首页> 外文期刊>Clinical and laboratory haematology >Spontaneous splenic haematoma in a multiple myeloma patient receiving pegfilgrastim support.
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Spontaneous splenic haematoma in a multiple myeloma patient receiving pegfilgrastim support.

机译:接受pegfilgrastim支持的多发性骨髓瘤患者的自发性脾血肿。

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摘要

Growth factors are a significant advance in the supportive care of patients with cancer with a wide range of indications. Frequent side effects of G-CSF include bone pain, headache, fatigue and nausea. We report a case of subcapsular splenic haematoma following pegfilgrastim administration in a 65-year old patient with multiple myeloma. Proposed mechanisms accounting for splenic enlargement include extramedullary haemopoiesis, intrasplenic infiltration by mature and immature myeloid cells and intrasplenic stem cell homing and proliferation. The risk of spontaneous splenic rupture is difficult to quantify. Physicians should be aware of this life-threatening condition and early diagnosis can be difficult since anemia and splenomegaly are common findings in haematologic patients.
机译:生长因子是在具有广泛适应症的癌症患者支持治疗中的重要进步。 G-CSF的常见副作用包括骨痛,头痛,疲劳和恶心。我们报告了一名65岁多发性骨髓瘤患者接受培格非司汀治疗后发生的囊下脾血肿的病例。提出的脾脏增大的机制包括髓外造血,成熟和未成熟髓样细胞的脾内浸润以及脾内干细胞归巢和增殖。自发性脾破裂的风险难以量化。医生应该意识到这种危及生命的状况,并且由于贫血和脾肿大是血液科患者的常见发现,因此很难进行早期诊断。

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