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Point-of-care testing of neonatal coagulation.

机译：新生儿凝血的即时检测。

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摘要

The aim of this validation study was to compare prothrombin time (PT) and activated partial thromboplastin time (APTT) results from a point-of-care testing (POCT) device (Rapidpoint Coag) with those from standard laboratory tests. The subjects were newborn infants needing coagulation screen for any clinical indications within a regional neonatal intensive care unit. The level of agreement between POCT and laboratory measurements of PT and APTT was determined. For PT: the bias was from -7.6 to 12.4 s and precision was 5.0 s. For the detection of prolonged PT at a level of 16 s, the sensitivity was 0.70, specificity was 0.57 and the positive predictive value (PPV) was 0.62. For APTT: the bias was from -39.1 to 23.7 s, and precision was 15.7 s. For the detection of prolonged APTT at a level of 55 s, the sensitivity was 0.80, specificity was 0.95 and the PPV was 0.80. The POCT device tested has limited utility as a cot-side device for screening for a prolongation of the APTT in the newborn but is not sensitive for screening for prolongation of the PT.
机译：该验证研究的目的是将即时检验（POCT）设备（Rapidpoint Coag）的凝血酶原时间（PT）和活化的部分凝血活酶时间（APTT）结果与标准实验室测试的结果进行比较。受试者是需要对区域新生儿重症监护病房内的任何临床指征进行凝血筛查的新生儿。确定了POCT与PT和APTT实验室测量值之间的一致性水平。对于PT：偏差为-7.6至12.4 s，精度为5.0 s。为了检测16 s时延长的PT，灵敏度为0.70，特异性为0.57，阳性预测值（PPV）为0.62。对于APTT：偏差为-39.1至23.7 s，精度为15.7 s。为了在55 s的水平上检测到延长的APTT，灵敏度为0.80，特异性为0.95，PPV为0.80。被测试的POCT装置作为婴儿床侧装置的用途有限，无法用于筛查新生儿APTT的延长，但对于筛查PT的延长不敏感。

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