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首页> 外文期刊>Clinical and laboratory haematology >Abnormal expansion of naive B lymphocytes after unrelated cord blood transplantation--a case report.
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Abnormal expansion of naive B lymphocytes after unrelated cord blood transplantation--a case report.

机译：无关的脐血移植后幼稚B淋巴细胞的异常扩增-病例报告。

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A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to be correlated with the expansion of CD19+ B cells. Although, compared with BMT, little is known about the kinetics of hematological and immunological reconstitution in U-CBT, there was initial B-cell recovery after CBT as some described. This B cell recovery may be associated with a high number of B-cell precursors present in cord blood (CB). The phenomenon of naive B lymphocyte expansion that we found might be associated with a high number of B-cell precursors present in CB.
机译：一名33岁妇女因骨髓增生异常综合征（MDS）相关的继发性AML接受了无关的脐血移植（U-CBT）。从U-CBT后约1个月到3个月，她的骨髓CD19 + B细胞和外周血CD19 + 27-IgD + B细胞数量显着增加。移植后IL-6的血清水平暂时升高，这种升高似乎与CD19 + B细胞的扩张有关。尽管与BMT相比，对U-CBT中血液和免疫重建的动力学知之甚少，但如某些描述的，在CBT后有最初的B细胞恢复。这种B细胞的恢复可能与脐带血（CB）中存在的大量B细胞前体有关。我们发现，幼稚的B淋巴细胞扩增现象可能与CB中存在的大量B细胞前体有关。

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