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首页> 外文期刊>Clinical and laboratory haematology >Venous stasis and routine hematologic testing.
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Venous stasis and routine hematologic testing.

机译：静脉淤滞和常规血液学检查。

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Prolonged venous stasis, as generated by a long tourniquet placement, produces spurious variations in several measurable analytes. To verify to what extent venous stasis influences routine hematologic testing, we assessed routine hematologic parameters, including hemoglobin, hematocrit, red blood cell count (RBC), main cell hemoglobin (MHC), main cell volume (MCV), platelet count (PLT), main platelet volume (MPV), white blood cell count (WBC) and WBC differential on the Advia 120 automated hematology analyzer in 30 healthy volunteers, either without venous stasis (no stasis) or after application of a 60 mmHg standardized external pressure by a sphygmomanometer, for 1 (1-min stasis) and 3 min (3-min stasis). Although the overall correlation between measures was globally acceptable, the mean values for paired samples were significantly different in all parameters tested, except MCV, MHC, PLT, MPV, eosinophils, basophils and large unstained cells after 1-min stasis and all parameters except MCV, MHC, MPV and basophils after 3-min venous stasis. As expected RBC, hemoglobin and hematocrit displayed a significant trend towards increase, whereas WBC and the WBC subpopulations were decreased. Difference between measurements by Bland and Altman plots exceeded the current analytical quality specifications for desirable bias for WBC, RBC, hemoglobin, hematocrit, lymphocytes and monocytes in samples collected after either 1- and 3-min stasis. These results provide clear evidence that venous stasis during venipuncture might produce spurious and clinically meaningful biases in the measurement of several hematologic parameters, prompting further considerations on the usefulness of adopting appropriate preventive measures for minimizing such influences.
机译：长时间的止血带放置会导致长时间的静脉停滞，从而在几种可测量的分析物中产生虚假的变化。为了验证静脉血瘀在多大程度上影响常规血液学检查，我们评估了常规血液学参数，包括血红蛋白，血细胞比容，红细胞计数（RBC），主细胞血红蛋白（MHC），主细胞量（MCV），血小板计数（PLT） ，30名健康志愿者在Advia 120自动血液分析仪上测定的主要血小板体积（MPV），白细胞计数（WBC）和WBC差异，无静脉淤滞（无淤滞）或经60 mmHg标准化外压施加血压计，持续1分钟（停滞1分钟）和3分钟（停滞3分钟）。尽管措施之间的总体相关性总体上是可以接受的，但是配对样本的平均值在所有测试参数上均存在显着差异，除了MCV，MHC，PLT，MPV，嗜酸性粒细胞，嗜碱性粒细胞和停滞1分钟后的大型未染色细胞以及除MCV以外的所有参数静脉停滞3分钟后出现MHC，MPV和嗜碱性粒细胞。如预期的那样，红细胞，血红蛋白和血细胞比容显示出明显的增加趋势，而白细胞和白细胞亚群减少。在停滞1分钟和3分钟后收集的样本中，通过Bland和Altman图进行的测量之间的差异超出了当前的分析质量规格，即WBC，RBC，血红蛋白，血细胞比容，淋巴细胞和单核细胞的理想偏差。这些结果提供了明确的证据，表明静脉穿刺过程中的静脉淤滞可能会在几种血液学参数的测量中产生虚假的和临床上有意义的偏差，促使人们进一步考虑采取适当的预防措施以最大程度地减少此类影响。

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