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首页> 外文期刊>Clinical and laboratory haematology >Isolated limb infusion with cytotoxic agent for treatment of localized refractory cutaneous T-cell lymphoma.
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Isolated limb infusion with cytotoxic agent for treatment of localized refractory cutaneous T-cell lymphoma.

机译：肢体输注用细胞毒剂治疗局部难治性皮肤T细胞淋巴瘤。

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摘要

We described a 57-yr-old male diagnosed with cutaneous T-cell lymphoma that had failed multiple treatment options, as his disease was mainly confined to one limb. We attempted a novel approach in this condition using a technique of intra-arterial limb infusion with cytotoxic agent Melphalan (ILI) which has been proven beneficial in management of localised malignant melanoma. This treatment approach was well tolerated with mild myelosuppression and moderate limb toxicity. However, a significant improvement has been noted in the affected limb. This case demonstrated the successful use of isolated limb infusion with Melphalan in the management of localised cutaneous T-cell lymphoma. However, this result needs to be confirmed and further study is recommended. We are unaware there have been similar cases reported in the literature.
机译：我们描述了一位57岁男性，被诊断患有皮肤T细胞淋巴瘤，但多种治疗方法均无效，因为他的疾病主要局限于一只肢体。我们在这种情况下尝试了一种新方法，采用动脉内肢体灌注细胞毒性剂美法仑（ILI）的技术，该技术已被证明对局部恶性黑色素瘤的治疗有益。轻度骨髓抑制和中度四肢毒性耐受性良好。但是，已注意到患肢明显改善。该病例证明了在肢体性皮肤T细胞淋巴瘤的治疗中成功应用美法仑进行独立肢体输注。但是，该结果有待确认，建议进一步研究。我们不知道文献中也有类似案例的报道。

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