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首页> 外文期刊>Biomacromolecules >Effect of Environmental Factors on Hydrolytic Degradation of Water-Soluble Polyphosphazene Polyelectrolyte in Aqueous Solutions
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Effect of Environmental Factors on Hydrolytic Degradation of Water-Soluble Polyphosphazene Polyelectrolyte in Aqueous Solutions

机译：环境因素对水溶液中水溶性聚磷腈聚电解质水解降解的影响

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Degradation of a water-soluble polyphosphazene, poly[di(carboxylatophenoxy)phosphazene], disodium salt (PCPP) has been studied in aqueous solutions at elevated temperature. This synthetic polyelectrolyte is of interest as vaccine adjuvant and its degradability constitutes an important component of its safety and formulation stability profiles. The degradation process is manifested by a gradual reduction in the molecular weight of the polymer and cleavage of side groups, which is consistent with previously reported data on hydrolytical breakdown of water-soluble polyphosphazenes. The kinetics of hydrolytical degradation exhibits distinct pH dependence and the process is faster in solutions with lower pH. Remarkably, a number of hydrogen bondiforming additives, such as polyethylene glycol and Tween displayed a dramatic accelerating effect on the degradation of PCPP, whereas inorganic salts, such as sodium chloride and potassium chloride, showed a trend for its retardation. The results can be potentially explained on the basis of acid promoted hydrolysis mechanism and macromolecular interactions in the system.
机译：在升高的温度下，已经研究了水溶性聚磷腈，聚[二（羧基苯甲氧基）磷腈]，二钠盐（PCPP）的降解。该合成的聚电解质作为疫苗佐剂是令人感兴趣的，并且其可降解性构成其安全性和制剂稳定性的重要组成部分。聚合物分子量的逐渐降低和侧基的裂解表明了降解过程，这与先前报道的水溶性聚磷腈的水解分解数据一致。水解降解的动力学表现出独特的pH依赖性，并且在具有较低pH的溶液中该过程更快。值得注意的是，许多形成氢键的添加剂（例如聚乙二醇和吐温）对PCPP的降解表现出显着的加速作用，而无机盐（例如氯化钠和氯化钾）则显示出其阻滞趋势。该结果可以根据酸促进的水解机理和系统中的大分子相互作用来解释。

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