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首页> 外文期刊>Clinical and laboratory haematology >Abnormal coagulation and deep venous thrombosis in patients with advanced cancer.
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Abnormal coagulation and deep venous thrombosis in patients with advanced cancer.

机译：晚期癌症患者的凝血异常和深静脉血栓形成。

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摘要

Many studies have demonstrated increased coagulation activation in cancer patients and have shown evidence of chronic, low-grade disseminated intravascular coagulation, although most patients remained asymptomatic. In general, patients have not been screened for deep venous thrombosis (DVT). We screened 98 patients with advanced malignancy for DVT using light reflection rheography. Coagulation profiles of DVT and non-DVT groups were studied. We found a high prevalence of DVT (50%) on screening. Overall, the patients had raised levels of fibrinogen (66% patients), factor VIII:C (43%), fragment 1 + 2 (71%) and TAT levels (89%). Patients with DVT had a significantly lower level of fibrinogen than those without (4.0 g/dl, SD 1.4, compared with 4.7 g/dl SD 1.6, P = 0.04). There was no significant difference in other coagulation or liver function tests between the DVT and non-DVT groups. The wide variation of results makes their interpretation difficult and unlikely to be of predictive value in estimating individual thrombotic risk.
机译：尽管大多数患者仍无症状，但许多研究表明癌症患者的凝血激活增强，并显示了慢性低度弥散性血管内凝血的证据。通常，尚未对患者进行深静脉血栓形成（DVT）筛查。我们使用光反射流变术筛查了98例DVT晚期恶性肿瘤患者。研究了DVT和非DVT组的凝血曲线。我们发现筛查中DVT的患病率很高（50％）。总体而言，患者的血纤蛋白原水平（66％患者），凝血因子VIII：C（43％），片段1 + 2（71％）和TAT水平（89％）升高。 DVT患者的血纤蛋白原水平明显低于无DVT的患者（4.0 g / dl，SD 1.4，而4.7 g / dl SD 1.6，P = 0.04）。 DVT组和非DVT组之间的其他凝血或肝功能检查无显着差异。结果的差异很大，使得它们的解释困难，并且在估计个体血栓形成风险中不太可能具有预测价值。

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