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首页> 外文期刊>Clinical and laboratory haematology >Solvent/detergent fresh frozen plasma as primary treatment of acute thrombotic thrombocytopenic purpura.
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Solvent/detergent fresh frozen plasma as primary treatment of acute thrombotic thrombocytopenic purpura.

机译：溶剂/洗涤剂新鲜冷冻血浆作为急性血栓性血小板减少性紫癜的主要治疗方法。

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Three patients with acute thrombotic thrombocytopenic purpura (TTP) (one associated with E. coli infection) received as primary treatment pooled fresh frozen plasma (FFP) virus inactivated by the solvent/detergent (SD) method, plus prednisolone. All three patients attained platelet counts of > 50 x 10(9)/l by days 7, 3 and 10, respectively. Serum creatinine became corrected in parallel. Neurological features were slow to resolve in one patient, and developed de novo during plasma infusion in another with rapid reversal once intensive plasma exchange with SDFFP was instituted. All patients are in stable remission > 1 years later. SDFFP was well tolerated with no febrile or other reactions, and all patients remained negative for markers of infection with HIV, hepatitis B and hepatitis C viruses. One patient was positive for antibodies for hepatitis A virus and parvovirus B19 prior to treatment. The other two patients remained antibody negative at the end of therapy.
机译：三例急性血栓性血小板减少性紫癜（TTP）（与大肠杆菌感染相关）的患者接受了一次初治，合并了通过溶剂/洗涤剂（SD）方法灭活的新鲜冰冻血浆（FFP）病毒和泼尼松龙。所有三名患者在第7、3和10天分别获得的血小板计数> 50 x 10（9）/ l。血清肌酐平行校正。一旦建立了与SDFFP的密集血浆交换，一名患者的神经系统特征就难以解决，而另一名患者在血浆输注过程中从头发展，然后迅速逆转。所有患者均在> 1年后稳定缓解。 SDFFP的耐受性良好，没有发热或其他反应，所有患者的HIV，乙型肝炎和丙型肝炎病毒感染指标均阴性。在治疗之前，一名患者的甲型肝炎病毒和细小病毒B19抗体呈阳性。其他两名患者在治疗结束时抗体阴性。

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