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首页> 外文期刊>Clinical and laboratory haematology >Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant.
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Circulating thrombopoietin in reactive conditions behaves like an acute phase reactant.

机译：在反应条件下循环血小板生成素的行为类似于急性期反应物。

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In a recent study we found elevated thrombopoietin (TPO) levels along with a trend toward correlation between serum TPO and some acute phase reactants (APR) in patients with reactive thrombocytosis. In order to further clarify the behaviour of TPO in reactive conditions and to highlight the eventual drawbacks of serum TPO (sTPO) against plasma TPO (pTPO) measurements, serial measurements were made of sTPO, pTPO, interleukin (IL)-6, C-reactive protein (CRP), fibrinogen (FBG), and erythrocyte sedimentation rate (ESR) in 12 patients before and at the 3rd, 7th, 14th, 45th day after hip replacement surgery. Platelet count, sTPO and pTPO were also measured in 30 healthy donors. As expected sTPO were significantly higher than pTPO levels (approximately 30% on average) both in controls (P < 0.00001) and in patients (P < 0.00001). Overall a very good correlation (r = 0.975, P < 0.00001) was found between serum and plasma TPO, whereas no correlation was found between platelet count and the sTPO/pTPO ratio indicating that the difference between sTPO and pTPO is independent from platelet count. So both serum and plasma seem to be suitable samples for TPO measurement if it is taken into account that sTPO are about 30% higher than pTPO. All the parameters we measured in our patients increased during the post-surgery period and returned to the basal value at the 45th day. pTPO levels peaked at the 3rd day, preceding by 11 days the peak in platelet count. A significant correlation was found between pTPO and ESR (P = 0.012), pTPO and FBG (P = 0.044), pTPO and CRP (P = 0.033), and a nearly significant correlation between pTPO and IL-6 (P = 0. 054). These results indicate that, in the course of reactive conditions, an early rise in TPO precedes and probably induces a later increase in platelet count. Moreover, the significant correlations along with the similarity in the chronological variations between TPO and some APRs suggest that TPO behave like an APR.
机译：在最近的研究中，我们发现反应性血小板增多症患者的血小板生成素（TPO）水平升高，以及血清TPO和某些急性期反应物（APR）之间的相关趋势。为了进一步阐明TPO在反应条件下的行为并强调血清TPO（sTPO）对血浆TPO（pTPO）测量的最终缺点，对sTPO，pTPO，白介素（IL）-6，C-髋关节置换术后第3天，第7天，第14天，第45天之前和之后的12例患者中反应蛋白（CRP），纤维蛋白原（FBG）和红细胞沉降率（ESR）。还测量了30名健康供体的血小板计数，sTPO和pTPO。正如预期的那样，在对照组（P <0.00001）和患者（P <0.00001）中，sTPO均显着高于pTPO水平（平均约30％）。总体而言，血清和血浆TPO之间存在非常良好的相关性（r = 0.975，P <0.00001），而血小板计数与sTPO / pTPO比率之间没有相关性，表明sTPO和pTPO之间的差异与血小板计数无关。因此，如果考虑到sTPO比pTPO高约30％，那么血清和血浆似乎都是适合TPO测量的样品。我们在患者中测量的所有参数在手术后均增加，并在第45天恢复到基础值。 pTPO水平在第3天达到峰值，比血小板计数的峰值提前11天。在pTPO和ESR之间（P = 0.012），pTPO和FBG（P = 0.044），pTPO和CRP（P = 0.033）之间发现了显着的相关性，而在pTPO和IL-6之间存在着显着的相关性（P =0。054） ）。这些结果表明，在反应条件下，TPO提前升高，并可能导致血小板计数随后升高。此外，TPO和一些APR之间的时间变化的相似性以及显着相关性表明TPO的行为类似于APR。

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