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首页> 外文期刊>Biochimica et Biophysica Acta. Molecular and cell biology of Lipids >Integrating the puzzle pieces: The current atomistic picture of phospholipid-G protein coupled receptor interactions
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Integrating the puzzle pieces: The current atomistic picture of phospholipid-G protein coupled receptor interactions

机译：整合拼图：磷脂-G蛋白偶联受体相互作用的当前原子图

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摘要

A compelling question of how phospholipids interact with their target receptors has been of interest since the first receptor-mediated effects were reported. The recent report of a crystal structure for the S1P 1 receptor in complex with an antagonist phospholipid provides interesting perspective on the insights that had previously been gained through structure-activity studies of the phospholipids, as well as modeling and mutagenesis studies of the receptors. This review integrates these varied lines of investigation in the context of their various contributions to our current understanding of phospholipid-receptor interactions. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
机译：自从报道了第一个受体介导的作用以来，关于磷脂如何与其靶受体相互作用的一个令人信服的问题就引起了人们的兴趣。 S1P 1受体与拮抗剂磷脂复合的晶体结构的最新报告为以前通过磷脂的结构活性研究以及受体的建模和诱变研究获得的见解提供了有趣的观点。这篇综述在对我们目前对磷脂-受体相互作用的理解的各种贡献的背景下综合了这些不同的研究方向。本文是名为“溶血磷脂研究进展”的特刊的一部分。

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