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首页> 外文期刊>日本磁気共鳴医学会雑誌 >Significance of Diffusion-weighted Imaging in Localized Renal Cell Carcinoma: Is Apparent Diffusion Coefficient a Predictor of Recurrence after Nephrectomy? [Presidential Award Proceedings]
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Significance of Diffusion-weighted Imaging in Localized Renal Cell Carcinoma: Is Apparent Diffusion Coefficient a Predictor of Recurrence after Nephrectomy? [Presidential Award Proceedings]

机译：弥散加权成像在局部肾细胞癌中的意义：表观弥散系数是肾切除术后复发的预测因子吗？ [总统颁奖程序]

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We evaluated whether the apparent diffusion coefficient (ADC) of a tumor is a predictor of recurrence after nephrectomy in localized renal cell carcinoma (RCC). Among 49 patients with localized RCC who underwent preoperative magnetic resonance imaging including diffusion-weighted imaging, 15 developed recurrence. On an ADC map, we measured the ADC by placing a region of interest in each tumor as avoiding necrosis and hemorrhage. We averaged ADC values obtained from 3 images to calculate the mean ADC, denning the minimum ADC as the lowest ADC value among the three. We used the Cox proportional hazards model to analyze correlations between clinicopathological variables that could affect recurrence (age, gender, tumor side, tumor size, growth/invasion pattern, Fuhrman grade, histological subtype, venous invasion, average ADC, and minimum ADC) and disease-free survival. Univariate analysis showed significant correlations of tumor size, venous invasion, mean ADC, and minimum ADC with disease-free survival (P<0.05). In multivariate analysis, only venous invasion and minimum ADC revealed significance (P<0.05). The 5-year disease-free survival rate of the group with venous invasion was 37.5%, of the group without venous invasion, 79.1%, of the group with low minimum ADC of 1.20 x 10~3 mm2/s or less, 37.5%, and of the group with low minimum ADC that exceeded 1.20 x 10~3 mm2/s, 85.1%. The minimum ADC of a tumor, as well as venous invasion, was an independent predictor of recurrence after nephrectomy in localized RCC.
机译：我们评估了肿瘤的表观扩散系数（ADC）是否是局部肾脏细胞癌（RCC）肾切除术后复发的预测指标。在49位接受了术前磁共振成像（包括弥散加权成像）的RCC局部患者中，有15例复发。在ADC图上，我们通过在每个肿瘤中放置一个感兴趣区域来避免坏死和出血来测量ADC。我们对从3张图像获得的ADC值进行平均，以计算平均ADC，将最小ADC定义为三个图像中的最低ADC值。我们使用Cox比例风险模型分析可能影响复发的临床病理变量之间的相关性（年龄，性别，肿瘤侧，肿瘤大小，生长/侵袭模式，Fuhrman分级，组织学亚型，静脉侵袭，平均ADC和最小ADC）和无病生存。单因素分析显示，肿瘤大小，静脉浸润，平均ADC和最小ADC与无病生存率显着相关（P <0.05）。在多变量分析中，仅静脉浸润和最小ADC显示出显着性（P <0.05）。静脉浸润组的5年无病生存率为37.5％，无静脉浸润组的为79.1％，最低ADC最低为1.20 x 10〜3 mm2 / s以下的组为37.5％。 ，最低ADC值最低的组超过1.20 x 10〜3 mm2 / s，占85.1％。肿瘤的最小ADC以及静脉侵袭是局部RCC肾切除术后复发的独立预测因子。

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