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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes.
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Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes.

机译：急性冠脉综合征患者的可溶性CD137和膜结合CD137水平提高。

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BACKGROUND: Increasing evidence shows that costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40 ligand and OX40/OX40 ligand have been implicated in atherosclerosis. We investigated whether the expression levels of the tumor necrosis factor superfamily members CD137 in serum and membrane-bound were related to acute coronary syndromes (ACS). METHODS: Thirty normal controls and 210 patients, including 70 with stable angina (SA), 80 with unstable angina (UA), and 60 with acute myocardial infarction (AMI), were enrolled in our study. The expression of CD137 in peripheral monocytes was analyzed by flow cytometry. Serum soluble CD137 (sCD137) and C-reactive protein levels were measured by commercially available ELISA. RESULTS: The expression of CD137 in peripheral monocytes in patients with UA [14.2+/-3.5 mean fluorescence intensity (MFI)] and AMI (15.1+/-4.4MFI) was significantly higher than those in patients with SA (6.5+/-2.4MFI) and controls (7.1+/-3.5MFI). sCD137 in patients with UA (16.7+/-4.9 ng/ml) and AMI (19.1+/-4.3 ng/ml) were significantly higher than those in patients with SA (3.4+/-1.4 ng/ml) and controls (3.9+/-1. 3 ng/ml) (p<0.001). C-reactive protein level in serum in patients with UA (13.8+/-3.3 ng/ml) and AMI (15.5+/-4.7 ng/ml) were also higher than those in patients with SA (1.4+/-0.4 ng/ml) and controls (1.3+/-0.3ng/ml). It was interesting that percutaneous transluminal coronary angioplasty (PTCA) induced a marked rise in sCD137 levels in SA patients, while CD137 expression in peripheral monocytes showed no difference between SA patients with PTCA before and after. A positive correlation was found between sCD137 and serum C-reactive protein levels (r=0.681; p<0.0001). CONCLUSION: Patients with ACS showed increased soluble and membrane-bound CD137 expression. sCD137 level showed a significantly positive correlation with CRP level in patients with ACS. The relation between sCD137 and ACS needs further researches.
机译：背景：越来越多的证据表明，肿瘤坏死因子超家族的共刺激分子（例如CD40 / CD40配体和OX40 / OX40配体）与动脉粥样硬化有关。我们调查了血清和膜结合的肿瘤坏死因子超家族成员CD137的表达水平是否与急性冠状动脉综合征（ACS）有关。方法：本研究共纳入30例正常对照和210例患者，包括70例稳定型心绞痛（SA），80例不稳定型心绞痛（UA）和60例急性心肌梗塞（AMI）。通过流式细胞术分析CD137在外周单核细胞中的表达。血清可溶性CD137（sCD137）和C反应蛋白水平通过市售ELISA测定。结果：UA [14.2 +/- 3.5平均荧光强度（MFI）]和AMI（15.1 +/- 4.4MFI）患者外周血单核细胞CD137的表达显着高于SA患者（6.5 +/- 2.4MFI）和控件（7.1 +/- 3.5MFI）。 UA（16.7 +/- 4.9 ng / ml）和AMI（19.1 +/- 4.3 ng / ml）患者的sCD137显着高于SA（3.4 +/- 1.4 ng / ml）和对照组（3.9 +/- 1。3 ng / ml）（p <0.001）。 UA（13.8 +/- 3.3 ng / ml）和AMI（15.5 +/- 4.7 ng / ml）患者的血清C反应蛋白水平也高于SA（1.4 +/- 0.4 ng / ml）患者ml）和对照（1.3 +/- 0.3ng / ml）。有趣的是，经皮腔内冠状动脉成形术（PTCA）导致SA患者的sCD137水平显着升高，而SA患者PTCA前后的外周血单核细胞CD137表达无差异。 sCD137与血清C反应蛋白水平之间呈正相关（r = 0.681; p <0.0001）。结论：ACS患者显示可溶性和膜结合的CD137表达增加。 sCD137水平与ACS患者的CRP水平呈显着正相关。 sCD137与ACS之间的关系有待进一步研究。

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