Direct arylation: Alternative to classic cross-coupling chemistry and a fruitful synthetic tool for the access to novative bioactive molecules

Florence Popowycz; Estelle Metay; Marc Lemaire

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Direct arylation: Alternative to classic cross-coupling chemistry and a fruitful synthetic tool for the access to novative bioactive molecules

机译：直接芳基化：可替代经典的交叉偶联化学反应，是获取创新生物活性分子的卓有成效的合成工具

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This account will discuss the advances performed in our group on direct arylation of heterocyclic systems regarded as critical scaffolds of pharmaceutical industries due to their wide-ranging biological and therapeutical properties. Applications to larger molecules devoted to pharmaceutical, material or agrochemical industries should bring significant improvement, getting rid of the preliminary step of prefunctionalization.

机译：本文将讨论我们小组在杂环系统的直接芳基化方面所取得的进展，这些杂环系统由于其广泛的生物学和治疗特性而被视为制药行业的关键支架。应用于专门用于制药，材料或农用化学工业的较大分子的应用应带来重大改进，摆脱预功能化的初步步骤。

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《Comptes Rendus Chimie》 |2011年第8期|共8页
作者
Florence Popowycz; Estelle Metay; Marc Lemaire;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Catalysis; Arylation; Synthetic methods; Bioactive molecules;

机译：催化;芳基化;合成方法;生物活性分子;

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专利

1. Direct arylation: Alternative to classic cross-coupling chemistry and a fruitful synthetic tool for the access to novative bioactive molecules [J] . Florence Popowycz, Estelle Metay, Marc Lemaire Comptes Rendus Chimie . 2011,第7a8期

机译：直接芳基化：可替代经典的交叉偶联化学反应，是获取创新生物活性分子的卓有成效的合成工具
2. An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence [J] . Sophie Marhadour, Marc-Antoine Bazin, Pascal Marchand Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2012,第3期

机译：通过Suzuki交叉偶联反应-直接芳基化序列通过咪唑[1,2-a]吡啶-2-基三氟甲酸酯有效地获得2,3-二芳基咪唑并[1,2-a]吡啶
3. Flow chemistry as a discovery tool to access sp(2)-sp(3) cross-coupling reactions via diazo compounds [J] . Tran Duc N., Battilocchio Claudio, Lou Shing-Bong, Chemical science . 2015,第2期

机译：流化学作为通过重氮化合物访问sp（2）-sp（3）交叉偶联反应的发现工具
4. The role of computational chemistry in translating genomic information into bioactive small molecules (abstract only) [C] . Yvonne Martin Proceedings of the Fifth annual international conference on Computational biology . 2001

机译：计算化学在将基因组信息转化为具有生物活性的小分子中的作用（仅摘要）
5. Nickel-Catalyzed Cross-Coupling Reactions: Stereospecific Arylations, Formation of 2-PyridylZinc Reagents & Directed Hydroarylation of Alkynes [D] . Hanna, Luke Edward. 2016

机译：镍催化的交叉偶联反应：立体特异性芳族，形成2-吡啶基锌试剂和炔烃的指导水序列
6. Flow chemistry as a discovery tool to access sp2–sp3 cross-coupling reactions via diazo compounds [O] . Duc N. Tran, Claudio Battilocchio, Shing-Bong Lou, 2015

机译：流动化学作为发现工具可通过重氮化合物访问sp2-sp3交叉偶联反应
7. Access to some C5-cyclised 2 pyrones and 2-pyridones via direct arylation; retention of chloride as a synthetic handle [O] . McGlacken, Gerard P., Fairlamb, Ian, Prendergast, Aisling, 2017

机译：通过直接芳基化反应获得一些C5环化的2个吡喃酮和2-吡啶酮；保留氯化物作为合成处理

Direct arylation: Alternative to classic cross-coupling chemistry and a fruitful synthetic tool for the access to novative bioactive molecules

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