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首页> 外文期刊>Clinical & developmental immunology. >Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients: Usefulness of Monitoring Peripheral Blood CD4~+ Adenosine Triphosphate Activity
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Immunological Aspects in Late Phase of Living Donor Liver Transplant Patients: Usefulness of Monitoring Peripheral Blood CD4~+ Adenosine Triphosphate Activity

机译：活体供肝移植患者后期的免疫学方面：监测外周血CD4〜+三磷酸腺苷活性的有用性

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Aim. To evaluate whether the combination of the peripheral blood CD4~+ adenosine triphosphate activity (ATP) assay (ImmuKnow assay: IMK assay) and cytochrome P450 3A5 (CYP3A5) genotype assay is useful for monitoring of immunological aspects in the patient followup of more than one year after living donor liver transplantation (LDLT). Methods. Forty-nine patients, who underwent LDLT more than one year ago, were randomly screened by using IMK assay from January 2010 to December 2011, and the complete medical records of each patient were obtained. The CYP3A5 genotypes were examined in thirty-nine patients of them. Results. The mean ATP level of the IMK assay was significantly lower in the patients with infection including recurrence of hepatitis C (HCV) (n = 10) than in those without infection (n = 39): 185 versus 350 ng/mL (P < 0.001), while it was significantly higher in the patients with rejection (n = 4) than in those without rejection (n = 45): 663 versus 306 ng/mL (P < 0.001). The IMK assay showed favorable sensitivity/specificity for infection (0.909/0.842) as well as acute rejection (1.0/0.911). CYP3A5 genotypes in both recipient and donor did not affect incidence of infectious complications. Conclusions. In the late phase of LDLT patients, the IMK assay is very useful for monitoring immunological aspects including bacterial infection, recurrence of HCV, and rejection.
机译：目标。为了评估外周血CD4〜+三磷酸腺苷活性（ATP）测定法（ImmuKnow测定法：IMK测定法）和细胞色素P450 3A5（CYP3A5）基因型测定法的组合是否可用于监测多于一项患者随访中的免疫学方面活体供肝移植（LDLT）后一年。方法。从2010年1月至2011年12月，通过IMK分析对49例接受LDLT超过一年的患者进行了随机筛查，并获得了每位患者的完整医疗记录。在其中的39例患者中检查了CYP3A5基因型。结果。 IMK分析的平均ATP水平在包括丙型肝炎（HCV）复发在内的感染患者中（n = 10）明显低于没有感染的患者（n = 39）：185 vs 350 ng / mL（P <0.001 ），而排斥反应患者（n = 4）明显高于无排斥反应的患者（n = 45）：663比306 ng / mL（P <0.001）。 IMK分析显示出良好的敏感性/特异性（0.909 / 0.842）和急性排斥反应（1.0 / 0.911）。 CYP3A5基因型在接受者和供者中均未影响感染并发症的发生率。结论在LDLT患者的晚期，IMK分析对于监测免疫学方面非常有用，包括细菌感染，HCV复发和排斥。

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