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首页> 外文期刊>Clinical & developmental immunology. >Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology
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Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology

机译：鞘脂和大脑常驻巨噬细胞在神经炎症：神经系统病理学的新兴方面。

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摘要

Sphingolipid metabolism is deeply regulated along the differentiation and development of the central nervous system (CNS), and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system. Microglia are resident macrophages of the CNS involved in general maintenance of neural environment. Modulations in microglia phenotypes may contribute to pathogenic forms of inflammation. Since defects in macrophage/microglia activity contribute to neurodegenerative diseases, it will be essential to systematically identify the components of the microglial cell response that contribute to disease progression. In such complex processes, the sphingolipid systems have recently emerged to play important roles, thus appearing as a key new player in CNS disorders. This review provides a rationale for harnessing the sphingolipid metabolic pathway as a potential target against neuroinflammation.
机译：鞘脂的代谢沿中枢神经系统（CNS）的分化和发展受到深层调节，特殊的空间和暂时调节的鞘脂模式的表达对于维持神经系统的功能完整性至关重要。小胶质细胞是参与中枢神经系统维护的中枢神经系统常驻巨噬细胞。小胶质细胞表型的调节可能导致炎症的致病形式。由于巨噬细胞/小胶质细胞活性的缺陷会导致神经退行性疾病，因此系统地鉴定有助于疾病进展的小胶质细胞反应成分至关重要。在这样复杂的过程中，鞘脂系统最近起着重要作用，因此成为中枢神经系统疾病的关键新参与者。这篇综述为利用鞘脂代谢途径作为抗神经炎症的潜在靶点提供了理论依据。

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