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Complement in Human Disease

机译：人类疾病的补充

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As part of innate immunity, the complement system embodies the "first line of defense" to various initial insults, including trauma, infection, hemorrhage, ischemia, and autoim-munity. While of beneficial intention, excessive complement activation can inadvertently damage healthy host tissues and thereby exacerbate the initial pathological events by causing an "innocent bystander effect.""Complementology" represents a rapidly evolving field. Recent scientific efforts have identified novel complement activation pathways and select complement-inhibiting compounds, which have been shown to ameliorate myriad autoimmune or inflammatory conditions. These findings have renewed the enthusiasm for novel pharmacological strategies targeting numerous inflammatory conditions, which currently elude successful transfer "from bench to bedside," such as acute lung injury, sepsis, burn, ischemia-reperfusion injury, traumatic brain injury, and kidney disease.
机译：作为先天免疫的一部​​分，补体系统体现了对各种初始损伤的“第一道防线”，包括创伤，感染，出血，局部缺血和自体免疫。尽管有益的意图是，过度的补体激活可通过引起“无辜的旁观者效应”而无意中破坏健康的宿主组织，从而加剧了初始病理事件。“补体”代表了快速发展的领域。最近的科学努力已经确定了新颖的补体激活途径并选择了抑制补体的化合物，这些化合物已被证明可以改善多种自身免疫或炎症性疾病。这些发现重新激发了针对多种炎性疾病的新型药理策略的热情，目前这些疾病尚无法成功地从“板凳到床边”转移，例如急性肺损伤，败血症，烧伤，局部缺血-再灌注损伤，脑外伤和肾脏疾病。

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