Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

Oxana V. Potapova; Tatyana V. Sharkova; Vyacheslav A. Shkurupiy; Alexer M. Shestopalov

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Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

机译：感染A / H5N1，A /鹅/ Krasnoozerskoye / 627/05株流感病毒的小鼠肝脏的免疫形态学表现

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Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-alpha, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.

机译：高致病性禽流感H5N1（HPAI H5N1）病毒可以感染哺乳动物，包括人类，从而导致严重的系统性疾病，并导致免疫系统受到抑制，死亡率很高。在淋巴组织枯竭的情况下，肝脏在宿主防御病毒中起着重要作用。研究了感染HPAI H5N1病毒A /鹅/ Krasnoozerskoye / 627/05的小鼠肝脏的变化。已经显示，病毒在肝脏中的持久性导致库普弗细胞表达促炎性细胞因子（TNF-α，IL-6）和细胞内蛋白酶（溶菌酶，组织蛋白酶D和髓过氧化物酶）。抗病毒反应缺陷会加剧肝脏中的破坏性过程，从而加速肝衰竭的发展。

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《Clinical & developmental immunology.》 |2013年第5期|共5页
作者
Oxana V. Potapova; Tatyana V. Sharkova; Vyacheslav A. Shkurupiy; Alexer M. Shestopalov;
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正文语种 eng
中图分类免疫性疾病;
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1. Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain [J] . Oxana V. Potapova, Tatyana V. Sharkova, Vyacheslav A. Shkurupiy, Clinical & developmental immunology. . 2013,第Pta5期

机译：感染A / H5N1，A /鹅/ Krasnoozerskoye / 627/05株流感病毒的小鼠肝脏的免疫形态学表现
2. Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain [J] . Oxana V.Potapova, Tatyana V.Sharkova, Vyacheslav A.Shkurupiy, Developmental Immunology: Journal of Immunology Research . 2013,第11期

机译：感染A / H5N1，A /鹅/ Krasnoozerskoye / 627/05株流感病毒的小鼠肝脏的免疫形态学表现
3. Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain [J] . Potapova Oxana V., Sharkova Tatyana V., Shkurupiy Vyacheslav A., Journal of immunology research. . 2013,第2期

机译：感染A / H5N1，A /鹅/ Krasnoozerskoye / 627/05株流感病毒的小鼠肝脏的免疫形态学表现
4. Histopathological effects of ethanolic extract of Gaharu's (Aquilaria malaccensis Lamk.) leaves on liver and kidney of mice (Mus musculus L.) infected by Plasmodium berghei [C] . Ardaning Nuriliani, Deby Lukmawati, Veggy Fazari Ameliya, International Conference on Biological Science . 2020

机译：疟原虫（Aquilaria malAccensis LAMK）乙醇提取物的组织病理学作用
5. Role of host cytokine responses in the pathogenicity and control of avian H5N1 influenza A viruses in mice [D] . Szretter, Kristy J. 2007

机译：宿主细胞因子应答在小鼠H5N1甲型禽流感病毒的致病性和控制中的作用
6. Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Strain [O] . Oxana V. Potapova, Tatyana V. Sharkova, Vyacheslav A. Shkurupiy, 2013

机译：感染A / H5N1A /鹅/ Krasnoozerskoye / 627/05株流感病毒的小鼠肝脏的免疫形态学表现
7. Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain [O] . Oksana Valentinovna Potapova, See Profile, Tatyana Vladimirovna Sharkova, 2013

机译：感染甲型流感/ H5N1，a /鹅/ Krasnoozerskoye / 627/05株的小鼠肝脏的免疫形态学表现

Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

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