• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical & developmental immunology. >Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7
【24h】

Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7

机译：LMW-HA刺激TLR4通过CXCR7诱导人乳头状甲状腺癌转移

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In inflammatory sites, high molecular weight hyaluronan fragments are degraded into lower molecular weight hyaluronan fragments (LMW-HA) to regulate immune responses. However, the function of LMW-HA in PTC progression remains to be elucidated. In this study, we found that receptor of LMW-HA, TLR4, was aberrantly overexpressed in PTC tissues and cell line W3. Exposure of W3 cells to LMW-HA promoted cell proliferation and migration via TLR4. Knockdown of TLR4 has provided evidence that TLR4 is essential for LMW-HA-induced CXCR7 expression, which is responsible for LMW-HA-induced proliferation and migration of W3 cells. In tumor-bearing adult nude mice, stimulation of LMW-HA on W3 cells promotes CXCR7 expression in tumor masses (P - 0.002) and tumor growth (P < 0.001). To further confirm our findings, we investigated the clinicopathologic significance of TLR4 and CXCR7 expression using immumohistochemistry in 135 human PTC tissues and 56 normal thyroid tissue samples. Higher rates of TLR4 (53%) and CXCR7 (24%) expression were found in PTC tissues than in normal tissues. Expression of TLR4 or CXCR7 is associated with tumor size and lymph node metastasis. Therefore, LMW-HA may contribute to the development of PTC via TLR4/CXCR7 pathway, which may be a novel target for PTC immunomodulatory therapy.
机译：在炎症部位，高分​​子量的透明质酸片段被降解为低分子量的透明质酸片段（LMW-HA），以调节免疫反应。然而，LMW-HA在PTC进展中的功能仍有待阐明。在这项研究中，我们发现LMW-HA的受体TLR4在PTC组织和细胞系W3中异常过表达。 W3细胞暴露于LMW-HA促进了细胞增殖和通过TLR4迁移。敲低TLR4提供了证据，表明TLR4对于LMW-HA诱导的CXCR7表达至关重要，该表达负责LMW-HA诱导的W3细胞增殖和迁移。在荷瘤成年裸鼠中，对W3细胞的LMW-HA刺激可促进肿瘤块中CXCR7表达（P-0.002）和肿瘤生长（P <0.001）。为了进一步证实我们的发现，我们使用免疫组织化学技术在135个人PTC组织和56个正常甲状腺组织样品中调查了TLR4和CXCR7表达的临床病理意义。在PTC组织中发现的TLR4（53％）和CXCR7（24％）的表达率高于正常组织。 TLR4或CXCR7的表达与肿瘤大小和淋巴结转移有关。因此，LMW-HA可能通过TLR4 / CXCR7途径促进PTC的发展，这可能是PTC免疫调节治疗的新目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号