• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical & developmental immunology. >The Role of T Helper (T_H)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation
【24h】

The Role of T Helper (T_H)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation

机译：T辅助（T_H）17细胞作为双刃剑在感染和自身免疫相互作用中的作用，重点是异源生物诱导的免疫调节

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Extensive research in recent years suggests that exposure to xenobiotic stimuli plays a critical role in autoimmunity induction and severity and that the resulting response would be exacerbated in individuals with an infection-aroused immune system. In this context, heavy metals constitute a prominent category of xenobiotic substances, known to alter divergent immune cell responses in accidentally and occupationally exposed individuals, thereby increasing the susceptibility to autoimmunity and cancer, especially when accompanied by inflammation-triggered persistent sensitization. This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events. Further, the T_H17 cell subset, known to be associated with a growing list of autoimmune manifestations, may be the "superstar" at the interface of xenobiotic exposure and autoimmunity. In this review, the most recently established links to this nomination are short-listed to create a framework to better understand new insights into T_H17's contributions to autoimmunity.
机译：近年来的大量研究表明，暴露于异源生物刺激物在自身免疫诱导和严重程度中起着关键作用，并且在具有感染引起的免疫系统的个体中，所产生的反应将加剧。在这种情况下，重金属构成了异种生物物质的主要类别，已知其会改变偶然和职业暴露的个体中不同的免疫细胞反应，从而增加自身免疫和癌症的易感性，尤其是在伴随炎症触发的持续致敏作用时。这种感觉是从感染和流行病学研究的实验模型中学到的，并且清楚地强调了暴露于此类免疫调节元素与暴露前或暴露后传染事件之间的相互作用。此外，已知与越来越多的自身免疫表现有关的T_H17细胞亚群可能是异源生物暴露和自身免疫之间的“超级巨星”。在本次审查中，与该提名最近建立的链接被短名单列出，以创建一个框架，以更好地了解T_H17对自身免疫的贡献的新见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号