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首页> 外文期刊>Clinical & developmental immunology. >Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127- T-Cells in Children with Long-Lasting Type 1 Diabetes
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Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127- T-Cells in Children with Long-Lasting Type 1 Diabetes

机译：长期持续的1型糖尿病儿童CD4 + T细胞上CD127表达降低和CD4 + CD25 + CD127-T细胞频率升高

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摘要

Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delineated by CD4+CD25+CD127- phenotype. Here we aimed to analyze CD127 expression on CD4+ and CD8+ T-cells and enumerate CD4+CD25+CD127- T-cells in long-lasting T1D. T-cells were analyzed by flow cytometry and immunologic data were correlated with vascular, metabolic, and inflammatory parameters. We demonstrated significantly decreased CD127 levels on CD4+, but not CD8+, T cells in T1D pediatric patients. Interestingly, frequencies of CD4+CD25+CD127-T-cells were significantly enhanced in T1D children and correlated well with frequencies of CD34+CD144+ endothelial progenitor cells and CD4+CD25- T-cells. Levels of CD127 on both CD4+ and CD8+ T-cells in T1D patients were not correlated to each other or HbA_(1C). Interestingly, however, CD127 levels on CD4+ T-cells were significantly correlated to frequencies of CD4+CD25+CD127-T-cells, whereas CD127 levels on CD8+ T-cells were significantly correlated to concentrations of VEGF and triglycerides. Our data indicate that GD127 expression is differentially modulated on CD4+ and CD8+ T-cells in the course of T1D. Moreover, we demonstrated that, in contrast to recent-onset T1D, long-lasting T1D is associated with enhancement of T-cells with regulatory phenotype.
机译：1型糖尿病（T1D）的病理生物学主要与T细胞相关的行为有关。大多数T细胞的稳态主要取决于CD127（白介素7受体，IL-7R）介导的信号。相反，调节性T细胞表达非常少的CD127，因此可以用CD4 + CD25 + CD127-表型来描述。在这里，我们旨在分析CD4 +和CD8 + T细胞上的CD127表达，并列举持久T1D中的CD4 + CD25 + CD127- T细胞。通过流式细胞仪分析T细胞，并将免疫学数据与血管，代谢和炎症参数相关。在T1D儿科患者中，我们证明CD4 + T细胞上的CD127水平显着降低，但CD8 + T细胞上没有降低。有趣的是，在T1D儿童中CD4 + CD25 + CD127-T细胞的频率显着增加，并与CD34 + CD144 +内皮祖细胞和CD4 + CD25-T细胞的频率很好地相关。 T1D患者中CD4 +和CD8 + T细胞上CD127的水平彼此不相关或与HbA_（1C）不相关。然而，有趣的是，CD4 + T细胞上的CD127水平与CD4 + CD25 + CD127-T细胞的频率显着相关，而CD8 + T细胞上的CD127水平与VEGF和甘油三酸酯的浓度显着相关。我们的数据表明，在T1D的过程中，GD127表达在CD4 +和CD8 + T细胞上有差异。此外，我们证明，与最近发作的T1D相反，持久的T1D与具有调节表型的T细胞的增强有关。

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