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首页> 外文期刊>Clinical & developmental immunology. >The Role of the Innate Immune System in Alzheimer's Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia
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The Role of the Innate Immune System in Alzheimer's Disease and Frontotemporal Lobar Degeneration: An Eye on Microglia

机译：先天性免疫系统在阿尔茨海默氏病和额颞叶变性中的作用：小胶质细胞的眼光。

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摘要

In the last few years, genetic and biomolecular mechanisms at the basis of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) have been unraveled. A key role is played by microglia, which represent the immune effector cells in the central nervous system (CNS). They are extremely sensitive to the environmental changes in the brain and are activated in response to several pathologic events within the CNS, including altered neuronal function, infection, injury, and inflammation. While short-term microglial activity has generally a neuroprotective role, chronic activation has been implicated in the pathogenesis of neurodegenerative disorders, including AD and FTLD. In this framework, the purpose of this review is to give an overview of clinical features, genetics, and novel discoveries on biomolecular pathogenic mechanisms at the basis of these two neurodegenerative diseases and to outline current evidence regarding the role played by activated microglia in their pathogenesis.
机译：在最近几年，已经阐明了基于阿尔茨海默氏病（AD）和额颞叶变性（FTLD）的遗传和生物分子机制。小胶质细胞起关键作用，小胶质细胞代表中枢神经系统（CNS）中的免疫效应细胞。它们对大脑中的环境变化极为敏感，并响应中枢神经系统内的多种病理事件而被激活，包括神经元功能改变，感染，损伤和炎症。虽然短期的小胶质细胞活动通常具有神经保护作用，但慢性激活已牵涉到神经退行性疾病（包括AD和FTLD）的发病机理中。在此框架下，本综述的目的是概述基于这两种神经退行性疾病的生物分子致病机制的临床特征，遗传学和新发现，并概述有关活化小胶质细胞在其发病机理中的作用的当前证据。

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