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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update
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Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update

机译：尿苷的稳态控制和尿苷磷酸化酶的作用：生物学和临床更新

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摘要

Uridine, a pyrimidine nucleoside essential for the synthesis of RNA and bio-membranes, is a crucial element in the regulation of normal physiological processes as well as pathological states. The biological effects of uridine have been associated with the regulation of the cardio-circulatory system, at the reproduction level, with both peripheral and central nervous system modulation and with the functionality of the respiratory system. Furthermore, uridine plays a role at the clinical level in modulating the cytotoxic effects of fluoropyrimidines in both normal and neoplastic tissues. The concentration of uridine in plasma and tissues is tightly regulated by cellular transport mechanisms and by the activity of uridine phosphorylase (UPase), responsible for the reversible phosphorolysis of uridine to uracil. We have recently completed several studies designed to define the mechanisms regulating UPase expression and better characterize the multiple biological effects of uridine. Immunohistochemical analysis and co-purification studies have revealed the association of UPase with the cytoskeleton and the cellular membrane. The characterization of the promoter region of UPase has indicated a direct regulation of its expression by the tumor suppressor gene p53. The evaluation of human surgical specimens has shown elevated UPase activity in tumor tissue compared to paired normal tissue.
机译：尿苷是合成RNA和生物膜必不可少的嘧啶核苷，是调节正常生理过程和病理状态的关键要素。尿苷的生物学效应与生殖循环中心脏循环系统的调节，外周和中枢神经系统的调节以及呼吸系统的功能有关。此外，尿苷在调节正常和赘生性组织中氟嘧啶的细胞毒性作用中在临床水平上发挥作用。血浆和组织中尿苷的浓度受到细胞转运机制和尿苷磷酸化酶（UPase）活性的严格控制，尿苷磷酸化酶负责尿苷可逆地磷酸化为尿嘧啶。我们最近完成了几项研究，旨在定义调节UPase表达的机制并更好地表征尿苷的多种生物学效应。免疫组织化学分析和共纯化研究表明，UPase与细胞骨架和细胞膜有关。 UPase启动子区域的特征表明，其抑癌基因p53直接调节了其表达。对人类手术标本的评估显示，与配对的正常组织相比，肿瘤组织中的UPase活性升高。

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