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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Simulation of axonal excitability using a Spreadsheet template created in Microsoft Excel.
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Simulation of axonal excitability using a Spreadsheet template created in Microsoft Excel.

机译：使用在Microsoft Excel中创建的电子表格模板模拟轴突兴奋性。

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摘要

The objective of this present study was to implement an established simulation protocol (A.M. Brown, A methodology for simulating biological systems using Microsoft Excel, Comp. Methods Prog. Biomed. 58 (1999) 181-90) to model axonal excitability. The simulation protocol involves the use of in-cell formulas directly typed into a spreadsheet and does not require any programming skills or use of the macro language. Once the initial spreadsheet template has been set up the simulations described in this paper can be executed with a few simple keystrokes. The model axon contained voltage-gated ion channels that were modeled using Hodgkin Huxley style kinetics. The basic properties of axonal excitability modeled were: (1) threshold of action potential firing, demonstrating that not only are the stimulus amplitude and duration critical in the generation of an action potential, but also the resting membrane potential; (2) refractoriness, the phenomenon of reduced excitability immediately following an action potential. The difference between the absolute refractory period, when no amount of stimulus will elicit an action potential, and relative refractory period, when an action potential may be generated by applying increased stimulus, was demonstrated with regard to the underlying state of the Na(+) and K(+) channels; (3) temporal summation, a process by which two sub-threshold stimuli can unite to elicit an action potential was shown to be due to conductance changes outlasting the first stimulus and summing with the second stimulus-induced conductance changes to drive the membrane potential past threshold; (4) anode break excitation, where membrane hyperpolarization was shown to produce an action potential by removing Na(+) channel inactivation that is present at resting membrane potential. The simulations described in this paper provide insights into mechanisms of axonal excitation that can be carried out by following an easily understood protocol.
机译：本研究的目的是实施建立的模拟方案（A.M. Brown，使用Microsoft Excel模拟生物系统的方法，Comp。Methods Prog。Biomed。58（1999）181-90），以对轴突兴奋性进行建模。模拟协议涉及直接输入电子表格中的单元内公式的使用，不需要任何编程技能或使用宏语言。一旦设置了初始电子表格模板，就可以通过一些简单的按键操作执行本文中描述的模拟。模型轴突包含使用Hodgkin Huxley型动力学建模的电压门控离子通道。轴突兴奋性的基本特性是：（1）动作电位激发阈值，表明不仅刺激振幅和持续时间对动作电位的产生至关重要，而且静息膜电位也很重要; （2）耐火度，一种动作电位后，兴奋性降低的现象。关于Na（+）的潜在状态，证明了绝对不应期（当没有任何量的刺激将不会引起动作电位时）与相对不应期（当通过施加增加的刺激可能产生动作电位时）之间的差异。和K（+）频道; （3）时间求和，这是两个亚阈值刺激可以联合以激发动作电位的过程，这是由于电导变化超过了第一个刺激，再加上第二个激励引起的电导变化来驱动膜电位过去。阈; （4）阳极断裂激发，其中膜超极化显示出通过消除存在于静止膜电位上的Na（+）通道失活而产生的动作电位。本文中描述的模拟提供了对轴突激发机制的见解，可以通过遵循易于理解的协议来进行。

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