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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Interactive image analysis programs for quantifying injury-induced axonal beading and microtubule disruption.
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Interactive image analysis programs for quantifying injury-induced axonal beading and microtubule disruption.

机译：交互式图像分析程序，用于量化损伤引起的轴突微珠和微管破裂。

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Focal axonal beading and focal disruption of microtubule structure are characteristic to traumatic axonal injury. We have recently reproduced these morphological and structural changes in our in vitro model system [D. Kilinc, G. Gallo, K.A. Barbee, Mechanically induced membrane poration causes axonal beading and localized cytoskeletal damage, Exp. Neurol. 212 (2008) 422-430]. In order to measure bead formation objectively, an observer-independent quantification of beading was necessary. In addition, a quantitative measure for the extent of co-localization of axonal beads and microtubule disruptions was required to establish a causal relationship between focal cytoskeletal damage and bead formation. In this paper we describe Matlab-based, interactive image analysis programs for axonal beading quantification and co-localization analysis. Injury-induced increases in the axonal beading could be successfully detected using the bead analysis program.
机译：局限性轴突珠化和微管结构的局灶性破坏是创伤性轴突损伤的特征。我们最近在体外模型系统中复制了这些形态和结构变化[D. Kilinc，G.Gallo，K.A. Barbee，机械诱导的膜穿孔会引起轴突成珠和局部细胞骨架损伤。神经元。 212（2008）422-430]。为了客观地测量珠的形成，有必要独立于观察者对珠进行定量。此外，需要定量的轴突珠和微管破坏的共定位程度，以建立局灶性细胞骨架损伤与珠形成之间的因果关系。在本文中，我们描述了基于Matlab的交互式图像分析程序，用于轴突微珠量化和共定位分析。使用珠子分析程序可以成功地检测到损伤引起的轴突珠子增加。

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