...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>麻酔 >Effects of sevoflurane and propofol on neuromuscular blocking action of Org 9426 (rocuronium bromide) infused continuously in Japanese patients
【24h】

Effects of sevoflurane and propofol on neuromuscular blocking action of Org 9426 (rocuronium bromide) infused continuously in Japanese patients

机译：七氟醚和异丙酚对日本人连续输注Org 9426（罗库溴铵）的神经肌肉阻滞作用的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The purpose of this study was to investigate the interaction of anesthetic agents with Org 9426 (rocuronium bromide) infused continuously. The effect of intubation dose of Org 9426 on its infusion rate was also investigated. METHODS: Total of 38 Japanese patients were randomly allocated either to receive intubation dose of 0.6 or 0.9 mg x kg(-1) of Org 9426. These patient groups were anesthetized with either sevoflurane or propofol. Infusion of Org 9426 was started with the initial infusion rate of 7 microg x kg(-1) x min(-1) when T1 reappeared after the intubation dose. The infusion rate was adjusted to keep the height of T1 between 3-10% of the control value. RESULTS: The rates of infusion 90 min after the start of infusion were 3.4, 7.5, 3.9 and 7.7 microg x kg(-1) x min(-1) for the 0.6 mg x kg(-1)-sevoflurane, 0.6 mg x kg(-1) propofol, 0.9 mg x kg(-1)-sevoflurane and 0.9 mg x kg(-1) propofol groups, respectively. Sevoflurane significantly reduced the infusion rate with both intubation doses. The mean infusion rates of 0.9 mg x kg(-1) groups were slower than those of 0.6 mg x kg(-1) groups up to 60 min after the start of infusion. Mean clearance of Org 9426 during infusion was not different between sevoflurane and propofol anesthesia. CONCLUSIONS: Patients receiving sevoflurane anesthesia required a markedly lower Org9426 infusion rate compared with patients receiving propofol anesthesia.
机译：背景：本研究的目的是研究麻醉剂与连续注入的Org 9426（罗库溴铵）的相互作用。还研究了Org 9426的插管剂量对其输注速率的影响。方法：总共38例日本患者被随机分配接受0.6或0.9 mg x kg（-1）的Org 9426插管剂量。这些患者组用七氟醚或丙泊酚麻醉。当在插管剂量后再次出现T1时，开始以7 microg x kg（-1）x min（-1）的初始输注速率开始输注Org 9426。调节输注速率以使T1的高度保持在对照值的3-10％之间。结果：对于0.6 mg x kg（-1）-七氟醚，0.6 mg x，开始输注后90分钟的输注速率分别为3.4、7.5、3.9和7.7 microg x kg（-1）x min（-1）。 kg（-1）异丙酚，0.9 mg x kg（-1）-七氟醚和0.9 mg x kg（-1）异丙酚组。在两种插管剂量下，七氟醚均显着降低了输液速度。在开始输注后的60分钟内，0.9 mg x kg（-1）组的平均输注速率比0.6 mg x kg（-1）组的平均输注速率慢。七氟醚和异丙酚麻醉期间输注期间Org 9426的平均清除率无差异。结论：与接受异丙酚麻醉的患者相比，接受七氟醚麻醉的患者需要的Org9426输注速率要低得多。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号