...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>麻酔 >The changes in hemodynamics and dose requirements in total intravenous anesthesia using propofol and buprenorphine
【24h】

The changes in hemodynamics and dose requirements in total intravenous anesthesia using propofol and buprenorphine

机译：异丙酚和丁丙诺啡全静脉麻醉的血流动力学和剂量要求的变化

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A retrospective study was performed to evaluate the changes in hemodynamics and dose requirements in total intravenous anesthesia (TIVA) using propofol and buprenorphine without (Group S: spinal surgery (3-6 h), n = 8, 28-79 Y) or with (Group A: abdominal surgery (5-10 h), n = 15, 36-83 Y) epidural anesthesia. All patients were premedicated with midazolam i.m. (2-5 mg). Anesthesia was maintained with a single dose of buprenorphine (Group S: 1.9 +/- 0.4 micrograms.kg-1, Group A: 2.0 +/- 0.5 micrograms.kg-1), propofol infusion and vecuronium with 40% oxygen in air. Group A was supplemented with continuous epidural anesthesia using 2% mepivacaine. In Group A, mean arterial pressure (MAP) and heart rate remained stable after the start of surgery. However, in Group S, 2 hours after the start of surgery MAP increased (P < 0.05) and remained elevated (P < 0.05) at higher levels than those in Group A. The maintenance dose of propofol in Group A (4.0 +/- 1.1 mg.kg-1.h-1) was significantly smaller than in Group S (6.5 +/- 0.9 mg.kg-1.h-1). In both groups, infusion rates of propofol were unchanged from 1 hour after the start to the end of surgery. Infusion rates of mepivacaine (5.2 +/- 0.9 ml.h-1) were unchanged following the increase 2 hours after the start of surgery. Awakening times were within 25 min (Group S 11.3 +/- 7.2 min vs Group A 14.7 +/- 7.3 min). There was no awareness during anesthesia in either group. The results suggest that additional continuous epidural anesthesia in TIVA would be useful to reduce propofol dose, to stabilize hemodynamic state and to obtain rapid recovery in anesthesia of long duration.
机译：进行了一项回顾性研究，以评估使用异丙酚和丁丙诺啡不使用（​​S组：脊柱外科手术（3-6小时），n = 8、28-79 Y）或使用异丙酚和丁丙诺啡时的总静脉麻醉（TIVA）的血流动力学和剂量要求的变化（A组：腹部手术（5-10 h），n = 15，36-83 Y）硬膜外麻醉。所有患者均接受咪达唑仑i.m. （2-5毫克）。用单剂量的丁丙诺啡（S组：1.9 +/- 0.4微克.kg-1，A组：2.0 +/- 0.5微克.kg-1），异丙酚输注和维库溴铵（在空气中含40％氧气）维持麻醉。 A组使用2％的甲哌卡因补充硬膜外连续麻醉。在A组中，手术开始后平均动脉压（MAP）和心率保持稳定。然而，在S组中，手术开始后2小时MAP升高（P <0.05），并以高于A组的水平保持升高（P <0.05）。A组的异丙酚维持剂量（4.0 +/- 1.1 mg.kg-1.h-1）明显小于S组（6.5 +/- 0.9 mg.kg-1.h-1）。两组的丙泊酚输注率从手术开始至手术结束1小时均未改变。开始手术后2小时，甲哌卡因（5.2 +/- 0.9 ml.h-1）的输注速率没有变化。唤醒时间在25分钟以内（S组11.3 +/- 7.2分钟，A组14.7 +/- 7.3分钟）。两组麻醉期间均无意识。结果表明，在TIVA中进行额外的硬膜外连续麻醉将有助于减少丙泊酚剂量，稳定血液动力学状态并在长时间麻醉中获得快速恢复。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号