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首页> 外文期刊>麻酔 >A case of successful thrombolysis by recombinant tissue plasminogen activator for postoperative pulmonary thromboembolism
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A case of successful thrombolysis by recombinant tissue plasminogen activator for postoperative pulmonary thromboembolism

机译：重组组织纤溶酶原激活剂成功溶栓治疗术后肺血栓栓塞的一例

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A 52-year-old female suspected of hypercoagulability underwent modified radical hysterectomy and left oophorectomy for uterus cancer and left giant ovarian tumor under general combined with epidural anesthesia. On the day after the operation, the patient complained of dyspnea and developed tachypnea, a low Spo2, and hypotension after the intermittent external pneumatic compression of the legs. Echocardiography showed acute right cardiac failure and pulmonary angiography revealed massive pulmonary thromboembolism. The patient fell into shock with severe hypotension and unconsciousness during the catheter fragmentation and aspiration therapy for pulmonary thrombi. Bolus intravenous injection of monteplase 1.6 million units, a mutant of tissue plasminogen activator with a longer half-life, rapidly improved the shock status and stabilized the hemodynamic condition. Monteplase would be useful for life-threatening pulmonary thromboembolism although the risk of hemorrhagic complication remains.
机译：一名怀疑高凝性的52岁女性在联合硬膜外麻醉的情况下接受了改良的子宫全切除术和左卵巢切除术，以治疗子宫癌和左大卵巢肿瘤。术后第二天，患者因腿部间歇性外部气压受压而出现呼吸困难和呼吸急促，Spo2降低和低血压。超声心动图显示急性右心衰竭，肺血管造影显示大量肺血栓栓塞。在导管碎裂和肺血栓抽吸治疗期间，患者因严重的低血压和神志不清而休克。 Bolus静脉注射monteplase 160万单位，这是一种组织纤溶酶原激活物的突变体，具有较长的半衰期，可迅速改善休克状态并稳定血液动力学状况。尽管仍存在出血并发症的风险，但孟普酶可用于危及生命的肺血栓栓塞。

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