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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment plans using the biologically effective uniform dose.
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A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment plans using the biologically effective uniform dose.

机译：图形用户界面工具包，用于使用生物学有效的统一剂量来规范，报告和比较剂量反应关系和治疗计划。

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摘要

A toolkit (BEUDcal) has been developed for evaluating the effectiveness and for predicting the outcome of treatment plans by calculating the biologically effective uniform dose (BEUD) and complication-free tumor control probability. The input for the BEUDcal is the differential dose-volume histograms of organs exported from the treatment planning system. A clinical database is built for the dose-response parameters of different tumors and normal tissues. Dose-response probabilities of all the examined organs are illustrated together with the corresponding BEUDs and the P(+) values. Furthermore, BEUDcal is able to generate a report that simultaneously presents the radiobiological evaluation together with the physical dose indices, showing the complementary relation between the physical and radiobiological treatment plan analysis performed by BEUDcal. Comparisons between treatment plans for helical tomotherapy and multileaf collimator-based intensity modulated radiotherapy of a lung patient were demonstrated to show the versatility of BEUDcal in the assessment and report of dose-response relations.
机译：已经开发了一种工具包（BEUDcal），用于通过计算生物学有效均匀剂量（BEUD）和无并发症的肿瘤控制概率来评估有效性并预测治疗计划的结果。 BEUDcal的输入是从治疗计划系统输出的器官的微分剂量-体积直方图。建立了用于不同肿瘤和正常组织的剂量反应参数的临床数据库。说明了所有检查器官的剂量反应概率以及相应的BEUD和P（+）值。此外，BEUDcal能够生成一份报告，该报告同时呈现放射生物学评估和物理剂量指数，显示出BEUDcal进行的物理和放射生物学治疗计划分析之间的互补关系。螺旋层析疗法和基于多叶准直仪的肺部强度调节放射疗法的治疗计划之间的比较表明，BEUDcal在评估和剂量反应关系中具有多功能性。

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