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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >A home environment test battery for status assessment in patients with advanced Parkinson's disease.
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A home environment test battery for status assessment in patients with advanced Parkinson's disease.

机译：家用环境测试电池，用于评估晚期帕金森氏病患者的状态。

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摘要

A test battery for assessing patient state in advanced Parkinson's disease, consisting of self-assessments and motor tests, was constructed and implemented on a hand computer with touch screen in a telemedicine setting. The aim of this work was to construct an assessment device, applicable during motor fluctuations in the patient's home environment. Selection of self-assessment questions was based on questions from an e-diary, previously used in a clinical trial. Both un-cued and cued tapping tests and spiral drawing tests were designed for capturing upper limb stiffnes, slowness and involuntary movements. The patient interface gave an audible signal at scheduled response times and was locked otherwise. Data messages in an XML-format were sent from the hand unit to a central server for storage, processing and presentation. In tapping tests, speed and accuracy were calculated and in spiral tests, standard deviation of frequency filtered radial drawing velocity was calculated. An overall test score, combining repeated assessments of the different test items during a test period, was defined based on principal component analysis and linear regression. An evaluation with two pilot patients before and after receiving new types of treatments was performed. Compliance and usability was assessed in a clinical trial (65 patients with advanced Parkinson's disease) and correlations between different test items and internal consistency were investigated. The test battery could detect treatment effect in the two pilot patients, both in self-assessments, tapping tests' results and spiral scores. It had good patient compliance and acceptable usability according to nine nurses. Correlation analysis showed that tapping results provided different information as compared to diary responses. Internal consistency of the test battery was good and learning effects in the tapping tests were small.
机译：在远程医疗环境中，在带有触摸屏的手持计算机上构建并实现了一个用于评估晚期帕金森病患者状态的测试电池，包括自我评估和运动测试。这项工作的目的是构建一种评估设备，该设备可用于患者家庭环境中的运动波动时。自我评估问题的选择基于先前在临床试验中使用的电子日记中的问题。无提示和提示敲击测试以及螺旋拉伸测试均旨在捕获上肢僵硬，缓慢和不自主运动。患者界面在预定的响应时间发出声音信号，否则被锁定。 XML格式的数据消息从手持设备发送到中央服务器以进行存储，处理和显示。在攻丝测试中，计算速度和精度，在螺旋测试中，计算频率滤波后的径向拉伸速度的标准偏差。基于主成分分析和线性回归，定义了总的测试分数，结合了在测试期间对不同测试项目的重复评估。在接受新型治疗之前和之后，对两名试点患者进行了评估。在一项临床试验（65例晚期帕金森氏病患者）中评估了依从性和可用性，并调查了不同测试项目与内部一致性之间的相关性。测试电池可以通过自我评估，敲击测试结果和螺旋评分来检测两名试点患者的治疗效果。据九名护士称，它具有良好的患者依从性和可接受的可用性。相关分析表明，与日记回复相比，敲击结果提供了不同的信息。测试电池的内部一致性良好，攻丝测试的学习效果很小。

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