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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Computer-aided vestibular autorotational testing of the vestibulo-ocular reflex in senile vestibular dysfunction.
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Computer-aided vestibular autorotational testing of the vestibulo-ocular reflex in senile vestibular dysfunction.

机译：老年前庭功能障碍中前庭眼反射的计算机辅助前庭自动旋转测试。

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BACKGROUND AND OBJECTIVE: Studies have already investigated vestibulo-ocular reflex (VOR) responses in elderly subjects, mostly at low frequencies (<1 Hz) during passive head turns, or continuous active head turns in a rotational chair. However, natural head movements usually occur at frequencies above 1 Hz and at varying rates, rather than at continuously increasing rates as tested in most studies to date. The aim of this study was to compare VOR responses within or between normal and bilateral peripheral vestibular hypofunction (BPVH) elderly subjects with a computer base program incorporating random active high-frequency head movements. SUBJECTS: Seventeen senior patients with bilateral peripheral vestibular hypofunction and 13 age-matched paid healthy subjects participated in this study. DESIGN: All the subjects performed 8s of active, side-to-side head motions at 1 Hz, 2 Hz and 3 Hz in response to four experimental conditions: (A) a stationary visual target; (B) a stationary visual target and a moving target with a horizontal trajectory; (C) a stationary visual target and a moving target with a spiral trajectory; and (D) a stationary visual target with combined horizontal- and vertical-spiral moving targets. RESULTS: Repeated-measures ANOVA showed that across the different frequencies of headshaking, a significant increase took place in the phase lag of the BPVH subjects (p<0.001) compared with the normal controls. Post hoc analysis showed significant within-group differences in BPVH subjects (1 Hz vs 2 Hz, 2 Hz vs 3 Hz) and normal controls (1 Hz vs 2 Hz, 1 Hz vs 3 Hz). A significant VOR gain took place among the BPVH subjects at 3 Hz VAT (p<0.001) as compared with 1 Hz VAT and no significant differences in VOR gain could be detected among the controls at either of these frequencies. Repeated-measures ANOVA revealed that under our test conditions, significant main effect was noted for VOR asymmetry (F=4.45, p<0.05). Post hoc analysis showed significant within-group differences in the BPVH subjects (test A vs test B, test A vs test C, and test A vs test D). CONCLUSIONS: Our results showed that the VAT paradigm can be improved by using concurrent horizontal and vertical moving targets. The VOR phase may be useful for differentiating VAT responses between BPVH and healthy elderly subjects. Moreover, the results of this study demonstrate that gains in VOR at different frequencies of headshaking and asymmetry during different test conditions can be useful parameters for within-group assessment.
机译：背景与目的：研究已经研究了老年受试者的前庭眼反射（VOR）反应，主要是在被动头转弯或旋转椅子上连续主动头转弯的低频（<1 Hz）下。但是，自然的头部运动通常在高于1 Hz的频率下以不同的速率发生，而不是像迄今为止大多数研究中所测试的那样以不断增加的速率发生。本研究的目的是通过计算机程序结合随机的主动高频头部运动，比较正常人和双侧周围前庭功能减退（BPVH）老年受试者内部或之间的VOR反应。受试者：17名老年患者双侧周围前庭功能低下和13名年龄匹配的付费健康受试者参加了这项研究。设计：所有受试者针对以下四个实验条件分别以1 Hz，2 Hz和3 Hz进行了8秒钟的主动左右头部运动：（A）固定的视觉目标; （B）具有水平轨迹的静止视觉目标和运动目标; （C）具有螺旋轨迹的静止视觉目标和运动目标; （D）具有水平和垂直螺旋运动目标组合的固定视觉目标。结果：重复测量方差分析表明，与正常对照组相比，在不同的摇晃频率下，BPVH受试者的相位滞后显着增加（p <0.001）。事后分析显示，BPVH受试者（1 Hz对2 Hz，2 Hz对3 Hz）和正常对照（1 Hz对2 Hz，1 Hz对3 Hz）的组内差异显着。与1 Hz VAT相比，BPVH受试者在3 Hz VAT时发生了显着的VOR增益（p <0.001），并且在这两个频率中的任何一个控件之间均未检测到VOR增益的显着差异。重复测量的方差分析表明，在我们的测试条件下，VOR不对称性表现出明显的主要作用（F = 4.45，p <0.05）。事后分析显示，BPVH受试者的组内差异显着（测试A与测试B，测试A与测试C，测试A与测试D）。结论：我们的结果表明，通过同时使用水平和垂直移动目标可以改善增值税范式。 VOR阶段可用于区分BPVH和健康的老年受试者之间的VAT反应。此外，这项研究的结果表明，在不同的测试条件下，在不同的摇头频率和不对称性下，VOR的增加可能是组内评估的有用参数。

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