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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Analysis of three T1DM simulation models for evaluating robust closed-loop controllers
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Analysis of three T1DM simulation models for evaluating robust closed-loop controllers

机译：三种用于评估鲁棒闭环控制器的T1DM仿真模型的分析

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摘要

This work compares three well-known models and simulators in terms of their use in the analysis and design of glucose controllers for patients with Type 1 Diabetes Mellitus (T1DM). The objective is to compare them in practical scenarios which include: model uncertainty, time variance, nonlinearities, glucose measurement noise, delays between subcutaneous and plasma levels, pump saturation, and real-time controller implementation. The pros and cons of all models/simulators are presented. Finally, the simulators are tested with different robust controllers in order to identify the difficulties in the design and implementation phases. To this end, three sources of uncertainty are considered: nonlinearities, time-varying behavior (intra-patient) and inter-patient differences.
机译：这项工作比较了三种著名的模型和模拟器在1型糖尿病（T1DM）患者血糖控制器的分析和设计中的用途。目的是在实际情况中进行比较，包括：模型不确定性，时间变化，非线性，葡萄糖测量噪声，皮下和血浆水平之间的延迟，泵饱和度和实时控制器实现。介绍了所有模型/模拟器的优缺点。最后，用不同的鲁棒控制器对模拟器进行测试，以识别设计和实施阶段的困难。为此，考虑了三个不确定性来源：非线性，时变行为（患者内）和患者间差异。

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