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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >An optimal closed-loop control strategy for mechanical chest compression devices: A trade-off between the risk of chest injury and the benefit of enhanced blood flow
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An optimal closed-loop control strategy for mechanical chest compression devices: A trade-off between the risk of chest injury and the benefit of enhanced blood flow

机译：机械式胸部按压装置的最佳闭环控制策略：在胸部受伤的风险与增加血流的益处之间进行权衡

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Objectives: The widespread application of chest compression (CC) as a first aid measure inevitably has the potential for both harm and benefit. The present study was therefore undertaken to design an optimal CC closed-loop control strategy (OCCCS) for mechanical CC devices that will present an effective trade-off between the risk of chest injury and the benefit of blood flow during CPR. Additionally, to evaluate the CC performance of the OCCCS, the differences between the OCCCS and the traditional mechanical CC method (TMCM) of performing standard CC were explored. Methods: Using the computer simulation technique, partial pressure of end-tidal CO 2 (PETCO2) and human chest stiffness are simulated based on the Babbs' model in present study. PETCO2 was regarded as a benefit factor (BF), which was divided into 3 levels, while chest stiffness was regarded as a risk factor (RF), which was divided into 4 levels. A benefit versus risk index (BRI) was also constructed for the comprehensive evaluation of risk and benefit. An OCCCS was developed with the combination of the BF, RF, BRI and fuzzy control strategy. A comparison between the OCCCS and TMCM was then performed based on computer simulations. Results: The OCCCS obtained a greater BRI and a better trade-off between risk and benefit than the TMCM in 6 out of a total 9 cases, and the OCCCS also resulted in a significantly improved cardiac output (CO) and PETCO2 in 6 of the 9 cases. The mean BRI, CO and PETCO2 resulting from the OCCCS were 5.69, 1.45. L/min and 15.51. mmHg, respectively, while the mean BRI, CO and PETCO2 resulting from TMCM were 4.76, 1.18. L/min and 13.26. mmHg, respectively. Conclusions: The OCCCS can provide safer and more effective CC during cardiopulmonary resuscitation (CPR) compared to the TMCM, and has great potential in the future mechanical CC device development.
机译：目标：胸部按压（CC）作为急救措施的广泛应用不可避免地具有危害和益处的潜力。因此，本研究旨在为机械CC设备设计最佳CC闭环控制策略（OCCCS），该策略将在CPR期间胸部受伤的风险与血液流动的益处之间取得有效的平衡。另外，为了评估OCCCS的CC性能，探讨了OCCCS与执行标准CC的传统机械CC方法（TMCM）之间的差异。方法：采用计算机模拟技术，根据Babbs模型对潮气末CO 2（PETCO2）分压和人的胸腔僵硬进行模拟。 PETCO2被认为是有益因子（BF），分为3个级别，而胸部僵硬被认为是危险因子（RF），分为4个级别。还构建了利益与风险指数（BRI），用于风险和利益的综合评估。开发了一种结合了BF，RF，BRI和模糊控制策略的OCCCS。然后，基于计算机模拟对OCCCS和TMCM进行了比较。结果：在总共9例患者中，有6例OCCCS的BRI更高，风险与收益之间的权衡要好于TMCM，并且OCCCS的6例中的心输出量（CO）和PETCO2也显着提高。 9例。 OCCCS产生的平均BRI，CO和PETCO2为5.69、1.45。 L / min和15.51。 mmHg，而TMCM产生的平均BRI，CO和PETCO2分别为4.76、1.18。 L / min和13.26。毫米汞柱。结论：与TMCM相比，OCCCS可以在心肺复苏（CPR）期间提供更安全，更有效的CC，并且在未来的机械CC设备开发中具有巨大的潜力。

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