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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Growth of the flat bones of the membranous neurocranium: A computational model
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Growth of the flat bones of the membranous neurocranium: A computational model

机译：膜状神经颅骨扁平骨的生长：计算模型

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This article assumes two stages in the formation of the bones in the calvaria, the first one takes into account the formation of the primary centers of ossification. This step counts on the differentiation from mesenchymal cells into osteoblasts. A molecular mechanism is used based on a system of reaction-diffusion between two antagonistic molecules, which are BMP2 and Noggin. To this effect we used equations whose behavior allows finding Turing patterns that determine the location of the primary centers. In the second step of the model we used a molecule that is expressed by osteoblasts, called Dxl5 and that is expressed from the osteoblasts of each flat bone. This molecule allows bone growth through its borders through cell differentiation adjacent to each bone of the skull. The model has been implemented numerically using the finite element method. The results allow us to observe a good approximation of the formation of flat bones of the membranous skull as well as the formation of fontanelles and sutures.
机译：本文假设颅骨中骨骼的形成分为两个阶段，第一个阶段考虑了骨化的主要中心的形成。该步骤依靠从间充质细胞向成骨细胞的分化。基于两个拮抗分子BMP2和Noggin之间的反应扩散系统，使用了分子机理。为此，我们使用方程的行为可以找到确定主要中心位置的图灵模式。在模型的第二步中，我们使用了一个由成骨细胞表达的分子，称为Dxl5，该分子由每个扁平骨的成骨细胞表达。该分子通过与头骨的每个骨骼相邻的细胞分化，使骨骼通过边界生长。该模型已使用有限元方法在数值上实现。结果使我们可以观察到膜状颅骨扁平骨的形成以及font门和缝线的形成的良好近似。

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