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Immune status of patients with different outcomes of acute hepatitis C

机译：急性丙型肝炎不同结局患者的免疫状况

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AIM: To ascertain parameters of immune response significant for prognosis of the disease outcome in patients with acute hepatitis C (AHC). MATERIAL AND METHODS: Seventy two examinees were divided into three groups: 30 patients of group 1 had AHC; 29 patients of group 2 had chronic hepatitis C (CHC) with the disease history 3-10 years; 13 AHC convalescents who had the disease 3-10 years ago. The control group consisted of 10 healthy subjects. The following parameters of immune status were studied: CD3+, CD4+, CD8+, CD16+, CD20+, HLA-DR+CD3+, CD95+, O-lymphocytes. RESULTS: By clinicobiochemical picture and the results of 12-month follow-up RT-PCR investigations of blood HCV RNA, AHC patients were divided into two groups: in 18 (72%) of 25 patients AHC became chronic, 7 (28%) patients achieved convalescence. The proportion and absolute number of subpopulations of lymphocytes CD8+, CD20+, CD16+ as well as CD4/CD8 in patients with AHC with different outcomes did not differ from the controls. AHC convalescents and patients with AHC transformation into chronic hepatitis had in the acute period of the disease much higher absolute number of subpopulations of the lymphocytes CD3+, CD4+, HLA-DR+CD3+ vs the controls. In patients with chronic hepatitis C with elevated levels of AlAT, 3-10 year follow-up registered significantly higher absolute amount of CD8+, CD3+, CD4+, HLA-DR+CD3+ vs the controls. Only patients with AHC which later became chronic had for 6 months of the disease significantly elevated absolute number of O-lymphocytes vs the controls. CONCLUSION: A high absolute count of O-lymphocytes in AHC patients may indicate probable development of chronic hepatitis C.
机译：目的：确定对于急性丙型肝炎（AHC）患者预后重要的免疫应答参数。材料与方法：72名受检者分为三组：第一组30例AHC;第二组30例。第2组中有29例患有慢性丙型肝炎（CHC），病史为3-10年。 3-10年前患有这种疾病的13名AHC疗养者。对照组由10名健康受试者组成。研究了以下免疫状态参数：CD3 +，CD4 +，CD8 +，CD16 +，CD20 +，HLA-DR + CD3 +，CD95 +，O淋巴细胞。结果：通过临床生化检查和12个月的血液HCV RNA追踪RT-PCR研究结果，AHC患者分为两组：25例患者中有18例（72％）成为慢性AHC，7例（28％）患者康复。结果不同的AHC患者中CD8 +，CD20 +，CD16 +以及CD4 / CD8淋巴细胞亚群的比例和绝对数量与对照组无差异。 AHC恢复期和AHC转化为慢性肝炎的患者在疾病的急性期与对照组相比，淋巴细胞CD3 +，CD4 +，HLA-DR + CD3 +的亚群绝对数要高得多。在患有AlAT水平升高的慢性丙型肝炎患者中，与对照组相比，3-10年的随访显示CD8 +，CD3 +，CD4 +，HLA-DR + CD3 +的绝对量明显更高。只有患有AHC且后来成为慢性的患者，与该对照组相比，该病在6个月的疾病中O淋巴细胞的绝对数量显着增加。结论：AHC患者中O淋巴细胞的绝对数量高可能表明慢性丙型肝炎可能发展。

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