• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Therapeutic effects of a fermented soy product on peanut hypersensitivity is associated with modulation of T-helper type 1 and T-helper type 2 responses.
【24h】

Therapeutic effects of a fermented soy product on peanut hypersensitivity is associated with modulation of T-helper type 1 and T-helper type 2 responses.

机译：发酵大豆产品对花生超敏反应的治疗作用与调节1型T辅助和2型T辅助反应有关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: ImmuBalance is a koji fungus (Aspergillus oryzae) and lactic acid fermented soybean product. This unique production process is believed to create a food supplement that helps to induce or maintain normal immune response. OBJECTIVE: To assess possible therapeutic effects of ImmuBalance on peanut (PN) hypersensitivity using a murine model of peanut allergy (PNA). METHODS: PN allergic C3H/HeJ mice were fed standard mouse chow containing 0.5% or 1.0% ImmuBalance (ImmuBalance 2X), radiation-inactivated 1.0% ImmuBalance (I-ImmuBalance 2X), or regular diet chow (sham) for 4 weeks, beginning 10 weeks after the initial PN sensitization, and then challenged with PN. Anaphylactic symptom scores, plasma histamine, serum PN specific-IgE levels and splenocyte cytokine profiles were determined. RESULTS: While 100% of sham-treated PNA mice developed anaphylactic reactions with a median score of 3.3 following PN challenge, only 50% of ImmuBalance, 30% of ImmuBalance 2X and 40% of I-ImmuBalance 2X-treated mice developed allergic reactions with median scores of 1.0, 0.4 and 0.5 respectively, which were significantly less than that in the sham-treated mice (P<0.05). Plasma histamine and PN specific-IgE levels were also significantly less in all treated mice than in sham-treated mice (P<0.05). Furthermore, IL-4, IL-5 and IL-13 production by PN-stimulated splenocytes in vitro from ImmuBalance fed mice were markedly reduced compared with sham-treated mice, whereas IFN-gamma production was moderately increased. TGF-beta and TNF-alpha production were similar. CONCLUSIONS: ImmuBalance protects against PN-induced anaphylaxis when administered as a food supplement in this model. Protection was associated with down-regulation of Th2 responses. This supplement may provide a potential novel therapy for PNA.
机译：背景：ImmuBalance是曲霉（米曲霉）和乳酸发酵大豆产品。据信这种独特的生产过程可产生有助于诱导或维持正常免疫反应的食品补充剂。目的：使用鼠类花生过敏（PNA）模型评估ImmuBalance对花生（PN）超敏反应的可能治疗作用。方法：PN过敏性C3H / HeJ小鼠从开始就喂含0.5％或1.0％ImmuBalance（ImmuBalance 2X），辐射灭活的1.0％ImmuBalance（I-ImmuBalance 2X）或常规饮食（假）的标准小鼠食物4周，开始最初的PN致敏后10周，然后用PN攻击。测定过敏性症状评分，血浆组胺，血清PN特异性IgE水平和脾细胞因子水平。结果：虽然100％的经假手术处理的PNA小鼠在PN攻击后出现过敏反应，中位评分为3.3，但只有50％的ImmuBalance，30％的ImmuBalance 2X和40％的I-ImmuBalance 2X小鼠发生了过敏性反应。中位数分别为1.0、0.4和0.5，显着低于假手术组（P <0.05）。在所有治疗的小鼠中，血浆组胺和PN特异性IgE水平也显着低于假治疗的小鼠（P <0.05）。此外，与假治疗的小鼠相比，由ImmuBalance喂养的小鼠体外受PN刺激的脾细胞的IL-4，IL-5和IL-13的产生明显减少，而IFN-γ的产生则有所增加。 TGF-β和TNF-α的产量相似。结论：在该模型中作为食品补充剂给药时，ImmuBalance可以防止PN引起的过敏反应。保护与Th2反应的下调相关。该补充剂可能为PNA提供潜在的新颖疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号