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首页> 外文期刊>Clinical and experimental allergy : >Low breast milk levels of long-chain n-3 fatty acids in allergic women, despite frequent fish intake.
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Low breast milk levels of long-chain n-3 fatty acids in allergic women, despite frequent fish intake.

机译：尽管经常摄入鱼，但过敏女性的母乳中长链n-3脂肪酸含量较低。

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BACKGROUND: Long-chain n-3 polyunsaturated fatty acids (PUFAs) have immune regulating and anti-inflammatory effects. However, their role in allergic disease is unclear. Allergic diseases are immunologically heterogeneous, and we hypothesized that n-3 fatty acid composition in serum and breast milk may vary according to clinical manifestations. Further, animal studies have shown reduction of serum-PUFA levels during allergic inflammation. OBJECTIVE: To investigate fatty acid composition in breast milk and serum from women with different atopic disease manifestations. Secondly, to determine whether low PUFA levels reflected insufficient intakes. METHODS: Fatty acids were analysed in breast milk and serum of women with atopic eczema and respiratory allergy (n=16), only respiratory allergy (n=7), as well as healthy women (n=22). Dietary intake of foods expected to affect long-chain n-3 PUFA levels were estimated by food-frequency questionnaire. The fatty acid pattern was related to diagnostic group and intake of relevant food items using a multivariate pattern recognition method (partial least squares projections to latent structures and discriminant analysis). Results Women with a combination of eczema and respiratory allergy had lower breast milk levels of several PUFAs (arachidonic acid, eicosapentaenoic acid, EPA, docosahexaenoic acid, DHA, and docosapentaenoic acid, DPA), and a lower ratio of long-chain n-3 PUFAs-6 PUFAs. Their PUFA levels differed not only from that of healthy women, but also from that of women with only respiratory allergy. The latter had a fatty acid pattern similar to that of healthy women. Despite low EPA, DHA and DPA levels women with eczema and respiratory allergy consumed no less fish than did healthy women. CONCLUSION & CLINICAL RELEVANCE: Our data suggest that reduced levels of long-chain n-3 fatty acids in serum and breast milk characterize women with extensive allergic disease including eczema, and are not related to low fish intake. Consumption of PUFAs during the allergic process may explain these findings.
机译：背景：长链n-3多不饱和脂肪酸（PUFA）具有免疫调节和抗炎作用。但是，它们在过敏性疾病中的作用尚不清楚。过敏性疾病在免疫学上是异质的，我们假设血清和母乳中的n-3脂肪酸组成可能会根据临床表现而变化。此外，动物研究表明，变态反应性炎症期间血清PUFA水平降低。目的：探讨具有不同特应性疾病表现的妇女的母乳和血清中脂肪酸的组成。其次，确定低PUFA水平是否反映摄入不足。方法：分析特应性湿疹和呼吸道过敏（n = 16），仅呼吸道过敏（n = 7）以及健康妇女（n = 22）的母乳和血清中的脂肪酸。通过食物频率问卷评估了预计会影响长链n-3 PUFA水平的食物的饮食摄入量。使用多变量模式识别方法（部分最小二乘法投影到潜在结构和判别分析），将脂肪酸模式与诊断组和相关食品的摄入量相关。结果合并湿疹和呼吸道过敏的妇女的几种PUFA（花生四烯酸，二十碳五烯酸，EPA，二十二碳六烯酸，DHA和二十二碳五烯酸，DPA）的母乳水平较低，长链n-3比例较低PUFA / n-6 PUFA。它们的PUFA水平不仅与健康女性不同，而且与仅具有呼吸道过敏的女性也不同。后者具有类似于健康女性的脂肪酸模式。尽管EPA含量较低，但湿疹和呼吸道过敏妇女的DHA和DPA摄入量却比健康妇女少。结论与临床意义：我们的数据表明，血清和母乳中长链n-3脂肪酸水平的降低是患有广泛性过敏性疾病（包括湿疹）的女性的特征，并且与低鱼摄入无关。过敏过程中食用PUFA可能解释了这些发现。

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