• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Increased serum thymus and activation-regulated chemokine and cutaneous T cell-attracting chemokine levels in children with atopic dermatitis.
【24h】

Increased serum thymus and activation-regulated chemokine and cutaneous T cell-attracting chemokine levels in children with atopic dermatitis.

机译：特应性皮炎患儿的血清胸腺和活化调节的趋化因子及吸引皮肤T细胞的趋化因子水平升高。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Thymus and activation-regulated chemokine (TARC) and cutaneous T cell-attracting chemokine (CTACK) are responsible for the trafficking of T helper type 2 lymphocytes into sites of allergic inflammation. OBJECTIVE: We tested whether these cytokines are useful markers for childhood atopic dermatitis (AD), and evaluated age-related differences in the levels of these chemokines. METHODS: Serum TARC and CTACK levels, total serum IgE levels, total eosinophil counts, and specific IgE levels were measured in 401 children. The patients were characterized as having atopic eczema (n=157), non-atopic eczema (n=107), or as healthy control subjects (n=137). RESULTS: Both TARC and CTACK levels in children with AD were significantly higher than those in healthy control subjects. Serum TARC and CTACK levels significantly correlated with disease severity both in children with atopic eczema and in children with non-atopic eczema. Serum TARC levels in children with AD significantly correlated with their serum CTACK levels. Serum TARC and CTACK levels decreased in accordance with their ages. CONCLUSION: Serum TARC and CTACK levels might be useful markers for disease severity both in children with atopic eczema and with non-atopic eczema. Serum TARC and CTACK levels decreased in accordance with their ages.
机译：背景：胸腺和激活调节趋化因子（TARC）和皮肤T细胞吸引趋化因子（CTACK）负责2型T辅助淋巴细胞向过敏性发炎部位的运输。目的：我们测试了这些细胞因子是否是儿童特应性皮炎（AD）的有用标记，并评估了这些趋化因子水平与年龄相关的差异。方法：对401名儿童进行了血清TARC和CTACK水平，总血清IgE水平，总嗜酸性粒细胞计数和特定IgE水平的测量。患者的特征是患有特应性湿疹（n = 157），非特应性湿疹（n = 107）或健康对照组（n = 137）。结果：AD患儿的TARC和CTACK水平均显着高于健康对照组。在患有特应性湿疹的儿童和非特应性湿疹的儿童中，血清TARC和CTACK水平与疾病严重程度显着相关。 AD儿童的血清TARC水平与其血清CTACK水平显着相关。血清TARC和CTACK水平根据年龄而降低。结论：特应性湿疹和非特应性湿疹患儿的血清TARC和CTACK水平可能是疾病严重程度的有用指标。血清TARC和CTACK水平根据年龄而降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号